| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02380-0021-0000-8 |
| Chemical Name: | Malaoxon |
| CASRN: | 1634-78-2 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 635239_SCE |
| Study Result: | Negative (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 01/22/1991 | Bone Marrow | 24 | Male | Mouse | B6C3F1 | subcutaneously implanted x 1, 24 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Phosphate Buffered Saline |
0 |
11585 | 25 | 2.32 | ± | 0.340 |
| 11586 | 25 | 2.89 | ± | 0.362 | |||
| 11587 | 25 | 3.92 | ± | 0.588 | |||
| 11588 | 25 | 2.53 | ± | 0.278 | |||
| Average | 2.92 | ± | 0.355 | ||||
| Test Chemical | Malaoxon |
7.5 |
11540 | 25 | 4.73 | ± | 0.475 |
| 11541 | 25 | 5.22 | ± | 0.650 | |||
| 11542 | 25 | 3.96 | ± | 0.414 | |||
| 11543 | 25 | 2.92 | ± | 0.383 | |||
| Average | 4.21 | ± | 0.501 | ||||
| Test Chemical | Malaoxon |
15 |
11545 | 25 | 8.17 | ± | 0.789 |
| 11546 | 25 | 3.20 | ± | 0.294 | |||
| 11547 | 25 | 4.26 | ± | 0.468 | |||
| 11548 | 25 | 3.65 | ± | 0.468 | |||
| Average | 4.82 | ± | 1.138 | ||||
| Test Chemical | Malaoxon |
30 |
11550 | 25 | 3.48 | ± | 0.375 |
| 11551 | 25 | 4.36 | ± | 0.629 | |||
| 11552 | 25 | 3.24 | ± | 0.433 | |||
| 11553 | 25 | 4.28 | ± | 0.385 | |||
| Average | 3.84 | ± | 0.282 | ||||
| Positive Control | Mitomycin-C |
0.5 |
11590 | 25 | 5.56 | ± | 0.542 |
| 11591 | 25 | 5.53 | ± | 0.477 | |||
| 11592 | 25 | 6.96 | ± | 0.492 | |||
| 11593 | 25 | 6.48 | ± | 0.444 | |||
| Average | 6.14 | ± | 0.353 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed