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Study Information
Study Attribute Value
CEBS Accession Number: 002-02193-0012-0000-0
Chemical Name: Furan
CASRN: 110-00-9
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 635376_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
11/24/1986 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 4686 50 4 8 0 0 0 0 0 12 0.24 0.08 24.00 8.00
    4687 50 16 10 0 0 0 0 1 27 0.54 0.34 54.00 34.00
    4688 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    4689 50 7 3 2 0 0 0 0 12 0.24 0.18 24.00 18.00
    4690 50 7 1 0 0 0 0 0 8 0.16 0.14 16.00 14.00
    4691 50 10 7 1 2 0 0 0 20 0.40 0.22 40.00 22.00
    4692 50 1 5 0 0 0 0 0 6 0.12 0.02 12.00 2.00
    4693 50 15 5 4 1 0 0 0 25 0.50 0.38 50.00 38.00
Average         7.5 5.1 0.9 0.4 0.0 0.0 0.1 14.0 0.28 0.17 28.00 17.00
± SEM                         0.06 0.05 6.43 4.93
 
Test Chemical Furan 
87.5       
 4646 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    4647 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    4648 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4649 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4650 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4651 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4652 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4653 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
Average         0.5 0.8 0.0 0.0 0.0 0.0 0.0 1.3 0.03 0.01 2.50 1.00
± SEM                         0.01 0.01 1.05 0.53
 
Test Chemical Furan 
175         
 4656 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4657 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4658 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4659 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4660 50 0 0 1 0 0 0 0 1 0.02 0.02 2.00 2.00
    4661 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4662 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    4663 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.4 0.3 0.1 0.0 0.0 0.0 0.0 0.8 0.02 0.01 1.50 1.00
± SEM                         0.00 0.00 0.33 0.38
 
Test Chemical Furan 
350         
 4667 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    4668 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    4669 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    4670 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    4671 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    4672 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4673 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4674 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         1.1 0.4 0.0 0.0 0.0 0.0 0.0 1.5 0.03 0.02 3.00 2.25
± SEM                         0.01 0.01 0.65 0.70
 
Vehicle Control No Stressor 
 0         
 4676 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4677 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4678 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4679 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    4680 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4681 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4682 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    4683 50 4 0 0 0 0 0 0 4 0.08 0.08 8.00 8.00
Average         1.0 0.1 0.0 0.0 0.0 0.0 0.0 1.1 0.02 0.02 2.25 2.00
± SEM                         0.01 0.01 1.03 1.00
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation