COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02193-0012-0000-0
Chemical Name: Furan
CASRN: 110-00-9
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 635376_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
04/12/1988 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 7774 50 51 1 1 0 1 0 0 54 1.08 1.06 34.00 34.00
    7775 50 60 13 3 0 0 0 4 80 1.60 1.34 48.00 42.00
    7776 50 7 3 2 1 1 0 0 14 0.28 0.20 16.00 12.00
    7777 50 20 11 1 0 0 0 0 32 0.64 0.42 38.00 28.00
    7778 50 27 10 2 0 0 0 0 39 0.78 0.58 32.00 22.00
    7779 50 17 3 2 0 1 0 0 23 0.46 0.40 26.00 24.00
    7780 50 31 3 1 0 2 0 3 40 0.80 0.74 34.00 34.00
    7781 50 27 9 2 0 1 0 1 40 0.80 0.62 30.00 24.00
Average         30.0 6.6 1.8 0.1 0.8 0.0 1.0 40.3 0.81 0.67 32.25 27.50
± SEM                         0.14 0.13 3.26 3.25
 
Test Chemical Furan 
62.5       
 7704 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7705 50 2 0 0 0 0 0 0 2 0.04 0.04 2.00 2.00
    7706 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    7707 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    7708 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7709 50 7 1 0 0 0 0 0 8 0.16 0.14 12.00 10.00
    7710 50 3 0 0 0 0 0 0 3 0.06 0.06 4.00 4.00
    7711 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         2.3 0.3 0.0 0.0 0.0 0.0 0.0 2.5 0.05 0.05 4.00 3.50
± SEM                         0.02 0.02 1.41 1.18
 
Test Chemical Furan 
125         
 7714 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7715 50 2 0 1 0 0 0 0 3 0.06 0.06 6.00 6.00
    7716 50 3 2 0 0 0 0 0 5 0.10 0.06 10.00 6.00
    7717 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7718 50 3 0 0 0 0 0 0 3 0.06 0.06 4.00 4.00
    7719 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    7720 50 3 1 0 0 0 0 0 4 0.08 0.06 6.00 4.00
    7721 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
Average         1.8 0.6 0.1 0.0 0.0 0.0 0.0 2.5 0.05 0.04 4.50 3.25
± SEM                         0.01 0.01 1.18 0.84
 
Test Chemical Furan 
250         
 7724 50 11 1 0 0 0 0 0 12 0.24 0.22 22.00 20.00
    7725 50 8 0 0 0 0 0 0 8 0.16 0.16 14.00 14.00
    7726 50 16 9 0 1 0 0 0 26 0.52 0.32 34.00 26.00
    7727 50 9 4 0 0 0 0 0 13 0.26 0.18 20.00 16.00
    7728 50 11 5 1 1 0 0 0 18 0.36 0.24 30.00 22.00
    7730 50 1 7 4 1 0 0 0 13 0.26 0.10 22.00 12.00
    7731 50 7 6 0 0 0 0 0 13 0.26 0.14 22.00 12.00
    7732 50 6 4 0 0 0 0 0 10 0.20 0.12 20.00 12.00
Average         8.6 4.5 0.6 0.4 0.0 0.0 0.0 14.1 0.28 0.19 23.00 16.75
± SEM                         0.04 0.03 2.20 1.89
 
Vehicle Control No Stressor 
 0         
 7764 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7765 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    7766 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7767 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    7768 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 2.00
    7769 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    7770 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
Average         0.9 0.6 0.0 0.0 0.0 0.0 0.0 1.4 0.03 0.02 2.57 1.43
± SEM                         0.01 0.01 0.84 0.57
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation