COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02193-0012-0000-0
Chemical Name: Furan
CASRN: 110-00-9
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 635376_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
01/09/1989 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
50         
 9398 50 23 7 0 0 0 0 0 30 0.60 0.46 16.00 10.00
    9399 50 36 23 0 0 0 0 0 59 1.18 0.72 54.00 48.00
    9400 50 7 15 0 1 0 0 0 23 0.46 0.14 28.00 10.00
    9402 50 74 12 4 0 1 0 0 91 1.82 1.58 38.00 30.00
    9403 50 50 13 2 1 0 0 0 66 1.32 1.04 42.00 32.00
    9404 50 13 10 0 0 0 0 0 23 0.46 0.26 24.00 18.00
    9405 50 30 9 1 0 0 0 0 40 0.80 0.62 34.00 26.00
Average         33.3 12.7 1.0 0.3 0.1 0.0 0.0 47.4 0.95 0.69 33.71 24.86
± SEM                         0.19 0.19 4.73 5.12
 
Test Chemical Furan 
62.5       
 9328 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9329 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9330 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9331 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9332 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9333 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9334 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9336 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.00 0.00 0.25 0.00
± SEM                         0.00 0.00 0.25 0.00
 
Test Chemical Furan 
125         
 9338 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9339 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9340 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9341 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    9342 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9343 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9344 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    9345 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         0.6 0.4 0.0 0.0 0.0 0.0 0.0 1.0 0.02 0.01 2.00 1.25
± SEM                         0.01 0.01 0.85 0.75
 
Test Chemical Furan 
250         
 9348 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    9349 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    9350 50 0 4 0 0 0 0 0 4 0.08 0.00 6.00 0.00
    9351 50 2 6 0 0 0 0 0 8 0.16 0.04 10.00 4.00
    9353 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.8 2.4 0.0 0.0 0.0 0.0 0.0 3.2 0.06 0.02 4.80 1.60
± SEM                         0.03 0.01 1.62 0.98
 
Vehicle Control No Stressor 
 0         
 9388 50 10 1 0 0 0 0 0 11 0.22 0.20 4.00 2.00
    9389 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9390 50 3 2 0 0 0 0 0 5 0.10 0.06 8.00 6.00
    9391 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9392 50 2 6 0 0 0 0 0 8 0.16 0.04 16.00 4.00
    9393 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9394 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9395 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
Average         1.9 1.6 0.0 0.0 0.0 0.0 0.0 3.5 0.07 0.04 4.25 1.50
± SEM                         0.03 0.02 1.91 0.82
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation