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Study Information
Study Attribute Value
CEBS Accession Number: 002-02193-0012-0000-0
Chemical Name: Furan
CASRN: 110-00-9
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 635376_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
04/02/1990 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
50         
 11010 50 28 8 2 0 0 0 0 38 0.76 0.60 34.00 22.00
    11011 50 9 14 0 1 0 0 0 24 0.48 0.18 34.00 16.00
    11012 50 11 10 4 0 0 0 0 25 0.50 0.30 22.00 18.00
    11013 50 24 10 0 0 0 0 0 34 0.68 0.48 26.00 20.00
    11014 50 21 10 0 0 0 0 1 32 0.64 0.44 32.00 26.00
    11015 50 18 4 0 0 0 0 0 22 0.44 0.36 20.00 16.00
    11016 50 7 8 2 0 0 0 0 17 0.34 0.18 20.00 14.00
    11017 50 6 4 0 0 0 0 0 10 0.20 0.12 14.00 12.00
Average         15.5 8.5 1.0 0.1 0.0 0.0 0.1 25.3 0.51 0.33 25.25 18.00
± SEM                         0.07 0.06 2.64 1.60
 
Test Chemical Furan 
62.5       
 10940 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    10941 50 4 0 0 0 0 0 0 4 0.08 0.08 6.00 6.00
    10942 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10944 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10945 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10946 50 4 0 0 1 0 0 0 5 0.10 0.08 10.00 8.00
    10947 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10948 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         1.9 0.5 0.0 0.1 0.0 0.0 0.0 2.5 0.05 0.04 4.75 3.50
± SEM                         0.01 0.01 1.13 0.91
 
Test Chemical Furan 
125         
 10950 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10951 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    10952 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10954 50 1 0 0 0 0 0 1 2 0.04 0.04 2.00 2.00
    10955 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10956 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    10957 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    10958 50 2 0 0 0 0 0 1 3 0.06 0.06 2.00 2.00
Average         1.6 0.4 0.0 0.0 0.0 0.0 0.3 2.3 0.05 0.04 3.75 3.00
± SEM                         0.01 0.01 0.88 0.53
 
Test Chemical Furan 
250         
 10960 50 16 2 0 1 0 0 1 20 0.40 0.34 30.00 26.00
    10961 50 16 6 1 0 0 0 0 23 0.46 0.34 38.00 28.00
    10962 50 9 0 0 0 0 0 0 9 0.18 0.18 18.00 18.00
    10963 50 7 1 0 0 0 0 1 9 0.18 0.16 16.00 14.00
    10964 50 11 4 1 0 0 0 0 16 0.32 0.24 28.00 22.00
    10965 50 2 0 2 0 0 0 0 4 0.08 0.08 8.00 8.00
    10966 50 10 2 0 0 0 0 0 12 0.24 0.20 22.00 18.00
    10967 50 10 2 0 0 0 0 1 13 0.26 0.22 24.00 22.00
Average         10.1 2.1 0.5 0.1 0.0 0.0 0.4 13.3 0.27 0.22 23.00 19.50
± SEM                         0.04 0.03 3.27 2.29
 
Vehicle Control No Stressor 
 0         
 11000 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11001 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11002 50 2 5 0 0 0 0 0 7 0.14 0.04 6.00 4.00
    11003 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11004 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    11005 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11006 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    11007 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.9 1.1 0.0 0.0 0.0 0.0 0.0 2.0 0.04 0.02 3.00 1.75
± SEM                         0.02 0.01 0.93 0.59
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation