COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02193-0012-0000-0
Chemical Name: Furan
CASRN: 110-00-9
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 635376_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
01/07/1992 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
50         
 12740 50 49 7 0 0 0 0 2 58 1.16 1.02 34.00 28.00
    12741 50 78 2 0 0 0 0 0 80 1.60 1.56 26.00 24.00
    12742 50 106 1 1 1 0 0 1 110 2.20 2.16 32.00 30.00
    12744 50 76 7 0 0 0 0 0 83 1.66 1.52 38.00 32.00
    12745 50 36 6 0 0 0 0 0 42 0.84 0.72 28.00 20.00
    12746 50 148 7 1 0 0 0 0 156 3.12 2.98 48.00 42.00
    12747 50 41 14 1 0 0 0 0 56 1.12 0.84 30.00 24.00
    12748 50 40 8 3 0 0 0 0 51 1.02 0.86 34.00 24.00
Average         71.8 6.5 0.8 0.1 0.0 0.0 0.4 79.5 1.59 1.46 33.75 28.00
± SEM                         0.27 0.28 2.43 2.42
 
Test Chemical Furan 
200         
 12671 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12672 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12673 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12674 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12675 50 1 4 0 0 0 0 0 5 0.10 0.02 8.00 2.00
    12676 50 3 1 1 0 0 0 0 5 0.10 0.08 10.00 8.00
    12677 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12679 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.8 1.0 0.1 0.0 0.0 0.0 0.0 1.9 0.04 0.02 3.50 1.75
± SEM                         0.01 0.01 1.35 0.96
 
Test Chemical Furan 
250         
 12680 50 0 5 0 0 0 0 0 5 0.10 0.00 8.00 0.00
    12681 50 6 2 0 0 0 0 0 8 0.16 0.12 14.00 12.00
    12682 50 5 5 0 0 0 0 0 10 0.20 0.10 16.00 8.00
    12683 50 5 1 0 1 0 0 0 7 0.14 0.10 12.00 10.00
    12684 50 5 7 0 0 0 0 0 12 0.24 0.10 22.00 8.00
    12685 50 7 8 0 0 0 0 0 15 0.30 0.14 24.00 14.00
    12686 50 3 2 0 0 0 0 0 5 0.10 0.06 10.00 6.00
    12687 50 6 7 0 0 0 0 1 14 0.28 0.14 26.00 14.00
Average         4.6 4.6 0.0 0.1 0.0 0.0 0.1 9.5 0.19 0.10 16.50 9.00
± SEM                         0.03 0.02 2.38 1.65
 
Test Chemical Furan 
300         
 12690 50 3 18 0 3 0 0 0 24 0.48 0.06 28.00 6.00
    12691 50 8 8 4 4 0 0 0 24 0.48 0.24 32.00 24.00
    12692 50 5 3 0 0 0 0 0 8 0.16 0.10 16.00 10.00
    12693 50 7 5 0 0 0 0 0 12 0.24 0.14 20.00 12.00
    12694 50 11 4 0 0 0 0 0 15 0.30 0.22 18.00 16.00
    12695 50 9 2 3 0 0 0 0 14 0.28 0.24 22.00 18.00
    12696 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    12697 50 9 2 1 1 0 0 0 13 0.26 0.20 24.00 18.00
Average         6.6 5.6 1.0 1.0 0.0 0.0 0.0 14.3 0.29 0.15 21.00 13.25
± SEM                         0.05 0.03 2.62 2.53
 
Vehicle Control No Stressor 
 0         
 12730 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12731 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    12732 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12733 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12734 50 1 3 0 0 0 0 0 4 0.08 0.02 6.00 2.00
    12735 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12736 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12737 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.6 0.6 0.0 0.0 0.0 0.0 0.0 1.3 0.03 0.01 2.25 1.25
± SEM                         0.01 0.01 0.96 0.53
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation