| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02193-0011-0000-9 |
| Chemical Name: | Furan |
| CASRN: | 110-00-9 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 635376_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 11/17/1986 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
4578 | 25 | 3.33 | ± | 0.383 |
| 4579 | 25 | 5.10 | ± | 0.733 | |||
| 4580 | 25 | 4.96 | ± | 0.562 | |||
| 4581 | 25 | 4.50 | ± | 0.547 | |||
| Average | 4.47 | ± | 0.401 | ||||
| Test Chemical | Furan |
87.5 |
4543 | 25 | 4.58 | ± | 0.412 |
| 4544 | 25 | 4.96 | ± | 0.401 | |||
| 4545 | 25 | 4.29 | ± | 0.549 | |||
| 4546 | 25 | 5.54 | ± | 0.562 | |||
| Average | 4.84 | ± | 0.270 | ||||
| Test Chemical | Furan |
175 |
4548 | 25 | 2.94 | ± | 0.427 |
| 4549 | 25 | 3.72 | ± | 0.441 | |||
| 4550 | 25 | 3.06 | ± | 0.276 | |||
| 4551 | 25 | 6.16 | ± | 0.630 | |||
| Average | 3.97 | ± | 0.750 | ||||
| Test Chemical | Furan |
350 |
4553 | 25 | 5.19 | ± | 0.612 |
| 4554 | 25 | 3.79 | ± | 0.338 | |||
| 4555 | 25 | 4.91 | ± | 0.438 | |||
| 4556 | 25 | 3.10 | ± | 0.373 | |||
| Average | 4.25 | ± | 0.488 | ||||
| Positive Control | Dimethylbenzanthracene |
100 |
4573 | 25 | 8.86 | ± | 0.827 |
| 4574 | 25 | 9.26 | ± | 0.829 | |||
| 4575 | 25 | 9.18 | ± | 0.932 | |||
| 4576 | 25 | 9.31 | ± | 1.051 | |||
| Average | 9.15 | ± | 0.101 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed