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Study Information
Study Attribute Value
CEBS Accession Number: 002-02170-0013-0000-6
Chemical Name: Eugenol
CASRN: 97-53-0
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 635999_CA
Study Result: Equivocal


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
03/29/1989 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Equivocal

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 11555 50 2 9 0 1 1 0 0 13 0.26 0.06 18.00 8.00
    11566 50 2 4 0 1 0 0 0 7 0.14 0.04 14.00 4.00
    11578 50 6 7 0 0 0 0 0 13 0.26 0.12 20.00 12.00
    11602 50 5 9 0 0 0 0 0 14 0.28 0.10 18.00 8.00
    11608 50 9 6 0 1 0 0 0 16 0.32 0.18 24.00 14.00
    11609 50 7 7 0 0 0 0 0 14 0.28 0.14 26.00 12.00
    11619 50 4 8 0 0 0 0 0 12 0.24 0.08 18.00 6.00
    11627 50 6 12 0 2 0 0 0 20 0.40 0.12 32.00 12.00
Average         5.1 7.8 0.0 0.6 0.1 0.0 0.0 13.6 0.27 0.11 21.25 9.50
± SEM                         0.03 0.02 2.03 1.24
 
Test Chemical Eugenol 
150         
 11603 50 1 4 0 0 0 0 1 6 0.12 0.04 6.00 2.00
    11611 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    11615 50 2 3 0 0 0 0 0 5 0.10 0.04 10.00 4.00
    11616 50 2 7 0 0 0 0 0 9 0.18 0.04 12.00 4.00
    11624 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    11628 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11630 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    11631 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.9 2.5 0.0 0.0 0.0 0.0 0.1 3.5 0.07 0.02 5.25 1.75
± SEM                         0.02 0.01 1.41 0.59
 
Test Chemical Eugenol 
300         
 11594 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11598 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11601 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    11604 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    11605 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    11613 50 0 4 0 0 0 0 1 5 0.10 0.02 8.00 0.00
    11614 50 3 1 0 0 0 0 0 4 0.08 0.06 6.00 6.00
    11620 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
Average         0.8 1.9 0.0 0.0 0.0 0.0 0.1 2.8 0.06 0.02 5.00 1.50
± SEM                         0.01 0.01 1.00 0.82
 
Test Chemical Eugenol 
600         
 11595 50 0 6 0 0 0 0 0 6 0.12 0.00 12.00 0.00
    11596 50 2 13 0 1 0 0 1 17 0.34 0.06 24.00 6.00
    11600 50 4 11 0 0 0 0 0 15 0.30 0.08 20.00 8.00
    11607 50 3 4 0 1 0 0 0 8 0.16 0.06 16.00 6.00
    11618 50 2 6 0 0 0 0 0 8 0.16 0.04 8.00 4.00
    11629 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    11632 50 12 5 3 1 1 0 0 22 0.44 0.32 20.00 10.00
Average         3.6 6.7 0.4 0.4 0.1 0.0 0.1 11.4 0.23 0.09 15.43 5.43
± SEM                         0.05 0.04 2.38 1.21
 
Vehicle Control No Stressor 
 0         
 11565 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    11568 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    11588 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    11599 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    11606 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    11612 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11617 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11626 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.6 1.8 0.0 0.0 0.0 0.0 0.0 2.4 0.05 0.01 4.75 1.25
± SEM                         0.01 0.00 0.75 0.37
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation