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Study Information
Study Attribute Value
CEBS Accession Number: 002-02170-0013-0000-6
Chemical Name: Eugenol
CASRN: 97-53-0
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 635999_CA
Study Result: Equivocal


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
09/06/1989 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Equivocal

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 12993 50 3 3 0 0 0 0 0 6 0.12 0.06 12.00 6.00
    12995 50 4 5 0 1 0 0 0 10 0.20 0.08 12.00 8.00
    12998 50 18 11 0 0 0 0 0 29 0.58 0.36 30.00 22.00
    13012 50 2 7 0 0 0 0 0 9 0.18 0.04 14.00 4.00
    13014 50 5 3 1 0 0 0 0 9 0.18 0.12 18.00 12.00
    13016 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    13019 50 6 5 0 0 0 0 0 11 0.22 0.12 12.00 8.00
    13021 50 5 4 0 0 0 0 1 10 0.20 0.12 16.00 10.00
Average         5.6 5.0 0.1 0.1 0.0 0.0 0.1 11.0 0.22 0.12 15.25 9.25
± SEM                         0.05 0.04 2.36 2.07
 
Test Chemical Eugenol 
450         
 12986 50 1 2 0 1 0 0 0 4 0.08 0.02 8.00 2.00
    12992 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12996 50 0 2 0 0 0 0 1 3 0.06 0.02 4.00 0.00
    13005 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13008 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    13011 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    13018 50 0 1 0 0 0 0 1 2 0.04 0.02 2.00 0.00
    13020 50 3 1 0 0 0 0 0 4 0.08 0.06 6.00 6.00
Average         0.6 1.0 0.0 0.1 0.0 0.0 0.3 2.0 0.04 0.02 3.25 1.25
± SEM                         0.01 0.01 1.00 0.75
 
Test Chemical Eugenol 
600         
 12987 50 1 1 0 0 0 0 1 3 0.06 0.04 4.00 2.00
    12990 50 1 3 0 0 0 0 0 4 0.08 0.02 4.00 2.00
    12991 50 1 3 0 0 0 0 0 4 0.08 0.02 6.00 2.00
    12997 50 1 1 0 0 0 0 1 3 0.06 0.04 2.00 2.00
    13000 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    13003 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    13007 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
Average         0.9 1.6 0.0 0.0 0.0 0.0 0.4 2.9 0.06 0.03 3.71 1.71
± SEM                         0.01 0.00 0.81 0.29
 
Vehicle Control No Stressor 
 0         
 12985 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    12988 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    12994 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    13002 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    13004 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    13006 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    13009 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13013 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         1.0 1.0 0.0 0.0 0.0 0.0 0.0 2.0 0.04 0.02 4.00 2.00
± SEM                         0.01 0.01 0.85 0.85
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation