| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02170-0012-0000-5 |
| Chemical Name: | Eugenol |
| CASRN: | 97-53-0 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 635999_SCE |
| Study Result: | Positive (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 10/17/1988 | Bone Marrow | 42 | Male | Mouse | B6C3F1 | IP/IJ x 1, 42 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
10322 | 25 | 6.03 | ± | 0.371 |
| 10332 | 25 | 4.41 | ± | 0.400 | |||
| 10338 | 25 | 4.25 | ± | 0.388 | |||
| 10351 | 25 | 4.46 | ± | 0.413 | |||
| Average | 4.78 | ± | 0.418 | ||||
| Test Chemical | Eugenol |
150 |
10336 | 25 | 4.87 | ± | 0.322 |
| 10352 | 25 | 4.62 | ± | 0.398 | |||
| 10353 | 25 | 3.90 | ± | 0.386 | |||
| 10357 | 25 | 4.16 | ± | 0.405 | |||
| Average | 4.38 | ± | 0.219 | ||||
| Test Chemical | Eugenol |
300 |
10340 | 26 | 4.15 | ± | 0.285 |
| 10341 | 25 | 4.31 | ± | 0.503 | |||
| 10345 | 25 | 4.47 | ± | 0.344 | |||
| 10348 | 25 | 4.26 | ± | 0.389 | |||
| Average | 4.30 | ± | 0.067 | ||||
| Test Chemical | Eugenol |
600 |
10339 | 25 | 6.10 | ± | 0.512 |
| 10343 | 25 | 6.03 | ± | 0.418 | |||
| 10355 | 25 | 7.11 | ± | 0.665 | |||
| 10356 | 25 | 4.45 | ± | 0.370 | |||
| Average | 5.91 | ± | 0.549 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
10324 | 25 | 11.84 | ± | 0.674 |
| 10327 | 25 | 12.43 | ± | 0.832 | |||
| 10337 | 25 | 12.86 | ± | 0.701 | |||
| 10358 | 25 | 12.32 | ± | 0.786 | |||
| Average | 12.37 | ± | 0.210 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed