| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02170-0012-0000-5 |
| Chemical Name: | Eugenol |
| CASRN: | 97-53-0 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 635999_SCE |
| Study Result: | Positive (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 03/14/1989 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
11423 | 25 | 4.88 | ± | 0.410 |
| 11432 | 25 | 5.84 | ± | 0.562 | |||
| 11437 | 24 | 6.38 | ± | 0.492 | |||
| 11451 | 25 | 4.92 | ± | 0.486 | |||
| Average | 5.49 | ± | 0.365 | ||||
| Test Chemical | Eugenol |
150 |
11435 | 25 | 6.08 | ± | 0.673 |
| 11439 | 25 | 6.20 | ± | 0.783 | |||
| 11440 | 23 | 4.54 | ± | 0.495 | |||
| 11442 | 25 | 5.16 | ± | 0.553 | |||
| Average | 5.52 | ± | 0.395 | ||||
| Test Chemical | Eugenol |
300 |
11433 | 25 | 6.18 | ± | 0.682 |
| 11436 | 25 | 7.32 | ± | 1.125 | |||
| 11444 | 25 | 5.66 | ± | 0.439 | |||
| 11445 | 25 | 10.56 | ± | 1.873 | |||
| Average | 7.44 | ± | 1.099 | ||||
| Test Chemical | Eugenol |
600 |
11434 | 25 | 6.28 | ± | 0.546 |
| 11441 | 25 | 7.92 | ± | 0.789 | |||
| 11443 | 24 | 3.92 | ± | 0.479 | |||
| 11447 | 25 | 8.52 | ± | 1.312 | |||
| Average | 6.69 | ± | 1.028 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
11428 | 25 | 9.95 | ± | 0.867 |
| 11431 | 25 | 12.36 | ± | 1.122 | |||
| 11454 | 25 | 13.52 | ± | 1.395 | |||
| 11458 | 25 | 15.40 | ± | 1.224 | |||
| Average | 12.81 | ± | 1.140 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed