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Study Information
Study Attribute Value
CEBS Accession Number: 002-01542-0005-0000-9
Chemical Name: 5-Methoxypsoralen
CASRN: 484-20-8
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 653449_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
07/23/1991 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 266058 50 2 0 0 0 0 0 0 2 0.04 0.04 0.00 4.00
    266061 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    266066 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    266077 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266084 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    266087 50 1 4 0 0 0 0 0 5 0.10 0.02 10.00 4.00
    266096 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    266101 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266102 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    266109 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.6 1.4 0.0 0.0 0.0 0.0 0.0 2.0 0.04 0.01 3.50 1.50
± SEM                         0.01 0.01 1.18 0.63
 
Test Chemical 5-Methoxypsoralen 
450         
 266014 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266035 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266044 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    266049 50 1 0 0 0 0 1 0 2 0.04 0.04 0.00 4.00
    266053 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266074 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266105 50 9 2 0 0 0 0 0 11 0.22 0.18 14.00 12.00
    266116 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 6.00
    266121 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    266129 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         1.8 0.5 0.0 0.0 0.0 0.1 0.0 2.4 0.05 0.04 2.75 3.25
± SEM                         0.03 0.02 1.77 1.46
 
Test Chemical 5-Methoxypsoralen 
900         
 266003 50 7 0 0 0 0 2 0 9 0.18 0.18 0.00 18.00
    266060 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266067 50 2 1 0 0 0 1 0 4 0.08 0.06 8.00 6.00
    266075 50 3 0 0 0 0 0 0 3 0.06 0.06 0.00 6.00
    266085 50 7 0 0 0 0 0 0 7 0.14 0.14 0.00 14.00
    266088 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266108 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 6.00
    266113 50 3 0 0 1 0 0 0 4 0.08 0.06 6.00 6.00
    266114 50 5 2 0 0 0 0 0 7 0.14 0.10 12.00 8.00
    266120 50 2 0 0 0 0 0 0 2 0.04 0.04 0.00 6.00
Average         3.9 0.5 0.0 0.1 0.0 0.4 0.0 4.9 0.10 0.09 4.00 8.75
± SEM                         0.02 0.02 1.65 1.64
 
Test Chemical 5-Methoxypsoralen 
1800         
 266027 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266033 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266051 50 1 0 0 0 0 1 0 2 0.04 0.04 0.00 8.00
    266054 50 4 4 0 0 0 0 0 8 0.16 0.08 16.00 8.00
    266072 50 9 1 1 0 0 0 0 11 0.22 0.20 22.00 20.00
    266083 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    266100 50 2 0 0 0 0 0 0 2 0.04 0.04 0.00 2.00
    266103 50 5 3 0 0 0 1 0 9 0.18 0.12 12.00 8.00
    266112 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    266128 50 0 0 0 0 0 1 0 1 0.02 0.02 0.00 2.00
Average         3.0 1.3 0.1 0.0 0.0 0.4 0.0 4.8 0.10 0.07 7.50 6.75
± SEM                         0.03 0.02 2.95 2.14
 
Vehicle Control No Stressor 
 0         
 266004 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266010 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266045 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    266057 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266107 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    266115 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266118 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266122 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    266124 50 2 0 0 0 0 0 0 2 0.04 0.04 0.00 4.00
    266125 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.4 0.4 0.0 0.0 0.0 0.0 0.0 0.8 0.02 0.01 1.00 0.75
± SEM                         0.01 0.01 0.53 0.53
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation