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Study Information
Study Attribute Value
CEBS Accession Number: 002-01542-0005-0000-9
Chemical Name: 5-Methoxypsoralen
CASRN: 484-20-8
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 653449_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
11/05/1991 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 277002 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    277003 50 1 1 0 0 0 0 0 2 0.04 0.02 2.00 2.00
    277024 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    277039 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    277059 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277072 50 4 5 0 0 0 0 0 9 0.18 0.08 14.00 8.00
    277078 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277083 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    277084 50 6 6 1 1 0 0 0 14 0.28 0.14 20.00 14.00
    277085 50 4 7 0 0 0 0 0 11 0.22 0.08 18.00 8.00
Average         2.0 3.0 0.1 0.1 0.0 0.0 0.0 5.3 0.11 0.04 8.25 4.25
± SEM                         0.04 0.02 2.76 1.83
 
Positive Control Dimethylbenzanthracene 
200         
 277005 50 5 4 0 0 0 0 0 9 0.18 0.10 14.00 10.00
    277006 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    277018 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277022 50 1 2 0 1 0 0 0 4 0.08 0.02 8.00 2.00
    277028 50 7 7 0 0 0 0 0 14 0.28 0.14 26.00 12.00
    277048 50 7 5 0 0 0 0 0 12 0.24 0.14 16.00 14.00
    277049 50 3 4 0 0 0 0 0 7 0.14 0.06 12.00 6.00
    277058 50 4 3 0 0 0 0 0 7 0.14 0.08 14.00 8.00
    277060 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277079 50 8 7 0 0 0 0 0 15 0.30 0.16 24.00 14.00
Average         4.4 4.1 0.0 0.1 0.0 0.0 0.0 8.6 0.17 0.09 14.50 8.25
± SEM                         0.03 0.02 2.77 1.87
 
Test Chemical 5-Methoxypsoralen 
450         
 277007 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    277013 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277016 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    277030 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277046 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    277050 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    277051 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    277054 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277068 50 2 0 0 0 0 0 0 2 0.04 0.04 0.00 4.00
    277092 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.6 0.9 0.0 0.0 0.0 0.0 0.0 1.5 0.03 0.01 2.25 1.25
± SEM                         0.01 0.01 0.96 0.53
 
Test Chemical 5-Methoxypsoralen 
900         
 277023 50 2 5 0 1 0 0 0 8 0.16 0.04 10.00 4.00
    277026 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277033 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    277035 50 1 1 0 0 0 0 0 2 0.04 0.02 6.00 4.00
    277070 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277076 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277090 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    277091 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    277096 50 0 4 0 1 0 0 0 5 0.10 0.00 10.00 0.00
    277098 50 4 2 0 0 0 0 0 6 0.12 0.08 10.00 8.00
Average         1.4 1.8 0.0 0.3 0.0 0.0 0.0 3.4 0.07 0.03 5.75 3.00
± SEM                         0.02 0.01 1.49 0.93
 
Test Chemical 5-Methoxypsoralen 
1800         
 277014 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    277031 50 5 2 0 0 0 6 0 13 0.26 0.22 16.00 14.00
    277041 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    277042 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    277044 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    277045 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    277074 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277087 50 4 1 0 2 0 1 0 8 0.16 0.10 14.00 10.00
    277101 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    277102 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         2.0 1.0 0.0 0.3 0.0 0.9 0.0 4.1 0.08 0.06 6.50 4.75
± SEM                         0.03 0.03 1.99 1.69
 
Vehicle Control No Stressor 
 0         
 277004 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277010 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    277025 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    277029 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277047 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277069 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    277089 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    277099 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    277103 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277105 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.1 1.0 0.0 0.0 0.0 0.0 0.0 1.1 0.02 0.00 2.25 0.25
± SEM                         0.01 0.00 0.80 0.25
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation