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Study Information
Study Attribute Value
CEBS Accession Number: 002-01065-0015-0000-0
Chemical Name: 1,2-Propylene oxide
CASRN: 75-56-9
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 669217_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
05/22/1989 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 10212 50 11 7 2 0 0 0 1 21 0.42 0.28 26.00 16.00
    10213 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10214 50 1 1 0 0 0 0 2 4 0.08 0.06 8.00 6.00
    10215 50 8 5 0 0 0 0 0 13 0.26 0.16 22.00 12.00
    10216 50 7 7 0 0 0 0 1 15 0.30 0.16 18.00 8.00
    10217 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    10218 50 4 2 0 0 0 0 0 6 0.12 0.08 8.00 6.00
    10219 50 12 5 2 0 0 0 0 19 0.38 0.28 22.00 18.00
Average         5.6 3.6 0.5 0.0 0.0 0.0 0.5 10.3 0.21 0.13 14.00 8.75
± SEM                         0.06 0.04 3.25 2.17
 
Test Chemical 1,2-Propylene oxide 
75         
 10142 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10143 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10144 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10145 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10146 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10147 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10148 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10149 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.01 0.00 0.50 0.25
± SEM                         0.01 0.00 0.50 0.25
 
Test Chemical 1,2-Propylene oxide 
150         
 10152 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10153 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    10154 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10155 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
    10156 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10157 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10158 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10159 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.3 0.6 0.0 0.0 0.0 0.0 0.0 0.9 0.02 0.01 1.50 0.50
± SEM                         0.01 0.01 0.50 0.50
 
Test Chemical 1,2-Propylene oxide 
300         
 10162 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10163 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    10164 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10165 50 1 5 0 0 0 0 0 6 0.12 0.02 8.00 2.00
    10166 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10168 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    10169 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    10170 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         0.9 1.5 0.0 0.0 0.0 0.0 0.0 2.4 0.05 0.02 4.25 1.75
± SEM                         0.01 0.00 0.88 0.45
 
Vehicle Control No Stressor 
 0         
 10202 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10203 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10204 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10205 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10206 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10207 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10209 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10210 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.5 0.01 0.01 1.00 0.75
± SEM                         0.00 0.00 0.38 0.37
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation