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Study Information
Study Attribute Value
CEBS Accession Number: 002-01065-0015-0000-0
Chemical Name: 1,2-Propylene oxide
CASRN: 75-56-9
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 669217_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
06/04/1991 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 11855 50 15 3 0 0 0 0 0 18 0.36 0.30 22.00 20.00
    11856 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11857 50 6 0 1 0 0 0 0 7 0.14 0.14 12.00 12.00
    11858 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    11860 50 4 1 0 0 0 0 0 5 0.10 0.08 8.00 6.00
    11862 50 8 3 0 0 0 0 0 11 0.22 0.16 16.00 10.00
    11863 50 18 2 0 0 0 0 0 20 0.40 0.36 28.00 24.00
    11864 50 2 2 0 0 0 0 0 4 0.08 0.04 4.00 2.00
Average         6.9 1.8 0.1 0.0 0.0 0.0 0.0 8.8 0.18 0.14 12.50 9.75
± SEM                         0.05 0.05 3.18 3.01
 
Test Chemical 1,2-Propylene oxide 
75         
 11795 50 3 2 0 0 0 0 0 5 0.10 0.06 10.00 6.00
    11796 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11797 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    11798 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    11799 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11800 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    11801 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11802 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.0 0.8 0.0 0.0 0.0 0.0 0.0 1.8 0.04 0.02 3.50 2.00
± SEM                         0.01 0.01 1.40 0.85
 
Test Chemical 1,2-Propylene oxide 
150         
 11805 50 4 1 0 0 0 0 0 5 0.10 0.08 10.00 8.00
    11806 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11807 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    11808 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    11809 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    11810 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11811 50 3 1 0 0 0 0 0 4 0.08 0.06 6.00 6.00
    11812 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
Average         2.4 0.6 0.0 0.0 0.0 0.0 0.0 3.0 0.06 0.05 5.75 4.75
± SEM                         0.01 0.01 1.03 0.75
 
Test Chemical 1,2-Propylene oxide 
300         
 11815 50 4 0 0 0 0 0 0 4 0.08 0.08 4.00 4.00
    11816 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11817 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    11818 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    11819 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    11820 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11821 50 0 2 1 0 0 0 0 3 0.06 0.02 6.00 2.00
    11822 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
Average         1.9 0.5 0.1 0.0 0.0 0.0 0.0 2.5 0.05 0.04 4.50 3.50
± SEM                         0.01 0.01 0.63 0.73
 
Vehicle Control No Stressor 
 0         
 11865 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
    11866 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11867 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    11868 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11869 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    11870 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11871 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11872 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.5 0.8 0.0 0.0 0.0 0.0 0.0 1.3 0.03 0.01 2.25 1.00
± SEM                         0.01 0.01 0.59 0.53
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation