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Study Information
Study Attribute Value
CEBS Accession Number: 002-01065-0015-0000-0
Chemical Name: 1,2-Propylene oxide
CASRN: 75-56-9
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 669217_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
01/11/1993 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 13440 50 12 0 0 0 0 0 1 13 0.26 0.26 18.00 18.00
    13441 50 10 2 0 0 0 0 0 12 0.24 0.20 14.00 12.00
    13442 50 5 3 0 0 0 0 0 8 0.16 0.10 12.00 8.00
    13443 50 15 1 0 0 0 0 0 16 0.32 0.30 24.00 22.00
    13444 50 16 1 1 0 0 0 0 18 0.36 0.34 22.00 20.00
    13445 50 5 2 0 0 0 0 0 7 0.14 0.10 12.00 10.00
    13446 50 7 1 0 0 0 0 0 8 0.16 0.14 14.00 12.00
    13447 50 7 1 0 0 0 0 0 8 0.16 0.14 16.00 14.00
Average         9.6 1.4 0.1 0.0 0.0 0.0 0.1 11.3 0.23 0.20 16.50 14.50
± SEM                         0.03 0.03 1.59 1.76
 
Test Chemical 1,2-Propylene oxide 
75         
 13370 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13372 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    13373 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13374 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13375 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13376 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    13377 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13378 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         0.8 0.1 0.0 0.0 0.0 0.0 0.0 0.9 0.02 0.02 1.75 1.50
± SEM                         0.01 0.01 0.59 0.63
 
Test Chemical 1,2-Propylene oxide 
150         
 13380 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 2.00
    13381 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13382 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13383 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13384 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    13385 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13386 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13387 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         0.9 0.4 0.0 0.0 0.0 0.0 0.0 1.3 0.03 0.02 2.25 1.50
± SEM                         0.01 0.00 0.45 0.33
 
Test Chemical 1,2-Propylene oxide 
300         
 13390 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    13391. 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    13392 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    13393 50 0 1 1 0 0 0 0 2 0.04 0.02 2.00 2.00
    13394 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    13395 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13396 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13397 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.9 0.3 0.1 0.0 0.0 0.0 0.0 1.3 0.03 0.02 2.25 2.00
± SEM                         0.01 0.01 0.59 0.65
 
Vehicle Control No Stressor 
 0         
 13430 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    13431 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13432 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13433 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    13434 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13435 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13436 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13437 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.4 0.01 0.01 0.75 0.50
± SEM                         0.01 0.01 0.53 0.50
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation