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Study Information
Study Attribute Value
CEBS Accession Number: 002-01065-0015-0000-0
Chemical Name: 1,2-Propylene oxide
CASRN: 75-56-9
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 669217_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
08/16/1993 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 13750 50 20 4 0 0 0 0 0 24 0.48 0.40 26.00 20.00
    13751 50 21 3 0 0 0 0 0 24 0.48 0.42 20.00 16.00
    13752 50 10 1 1 0 0 0 0 12 0.24 0.22 20.00 18.00
    13753 50 18 1 1 0 0 0 0 20 0.40 0.38 32.00 30.00
    13754 50 23 2 0 1 0 0 0 26 0.52 0.46 34.00 30.00
    13755 50 10 3 0 0 0 0 0 13 0.26 0.20 22.00 18.00
    13756 50 8 4 0 0 0 0 0 12 0.24 0.16 20.00 16.00
    13757 50 23 6 0 0 0 0 0 29 0.58 0.46 34.00 28.00
Average         16.6 3.0 0.3 0.1 0.0 0.0 0.0 20.0 0.40 0.34 26.00 22.00
± SEM                         0.05 0.04 2.27 2.20
 
Test Chemical 1,2-Propylene oxide 
75         
 13680 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13681 50 4 0 0 0 0 0 0 4 0.08 0.08 8.00 8.00
    13682 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    13683 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 2.00
    13684 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13685 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    13686 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    13687 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.9 0.5 0.0 0.0 0.0 0.0 0.0 1.4 0.03 0.02 2.50 1.50
± SEM                         0.01 0.01 0.91 0.98
 
Test Chemical 1,2-Propylene oxide 
150         
 13690 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    13691 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13692 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    13693 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13694 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13695 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    13696 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13697 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.5 0.3 0.0 0.0 0.0 0.0 0.0 0.8 0.02 0.01 1.50 1.00
± SEM                         0.01 0.01 0.63 0.53
 
Test Chemical 1,2-Propylene oxide 
300         
 13700 50 5 1 0 0 0 0 0 6 0.12 0.10 8.00 6.00
    13701 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    13702 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    13703 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13704 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    13705 50 3 1 0 0 0 0 0 4 0.08 0.06 6.00 6.00
    13706 50 4 0 0 0 0 0 0 4 0.08 0.08 8.00 8.00
    13707 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         2.1 0.6 0.0 0.0 0.0 0.0 0.0 2.8 0.06 0.04 4.75 3.75
± SEM                         0.01 0.01 0.92 0.96
 
Vehicle Control No Stressor 
 0         
 13740 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13741 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13742 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13743 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    13744 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13745 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13746 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13748 50 1 3 0 0 0 0 0 4 0.08 0.02 6.00 2.00
Average         0.8 0.4 0.0 0.0 0.0 0.0 0.0 1.1 0.02 0.02 2.00 1.50
± SEM                         0.01 0.01 0.93 0.73
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation