| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01065-0014-0000-9 |
| Chemical Name: | 1,2-Propylene oxide |
| CASRN: | 75-56-9 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 669217_SCE |
| Study Result: | Positive (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 05/24/1989 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Positive (Nonstandard Protocol) |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Phosphate Buffered Saline |
0 |
10260 | 25 | 7.32 | ± | 0.791 |
| 10261 | 25 | 3.20 | ± | 0.497 | |||
| 10262 | 25 | 3.74 | ± | 0.437 | |||
| 10263 | 25 | 4.45 | ± | 0.468 | |||
| Average | 4.68 | ± | 0.918 | ||||
| Test Chemical | 1,2-Propylene oxide |
75 |
10232 | 25 | 5.33 | ± | 0.576 |
| 10233 | 25 | 6.37 | ± | 0.494 | |||
| 10234 | 25 | 3.08 | ± | 0.400 | |||
| Average | 4.93 | ± | 0.972 | ||||
| Test Chemical | 1,2-Propylene oxide |
150 |
10235 | 25 | 4.25 | ± | 0.524 |
| 10236 | 25 | 4.45 | ± | 0.611 | |||
| 10237 | 25 | 6.20 | ± | 0.687 | |||
| 10238 | 25 | 4.89 | ± | 0.476 | |||
| Average | 4.95 | ± | 0.439 | ||||
| Test Chemical | 1,2-Propylene oxide |
300 |
10240 | 25 | 9.64 | ± | 0.599 |
| 10242 | 25 | 8.17 | ± | 0.721 | |||
| 10243 | 25 | 12.80 | ± | 1.009 | |||
| 10244 | 25 | 14.77 | ± | 1.390 | |||
| Average | 11.35 | ± | 1.496 | ||||
| Positive Control | Mitomycin-C |
0.5 |
10265 | 25 | 7.32 | ± | 0.506 |
| 10266 | 25 | 8.17 | ± | 0.573 | |||
| 10267 | 25 | 8.28 | ± | 0.708 | |||
| 10268 | 25 | 6.08 | ± | 0.683 | |||
| Average | 7.46 | ± | 0.508 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed