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Study Information
Study Attribute Value
CEBS Accession Number: 002-02837-0012-0000-5
Chemical Name: Stannous chloride
CASRN: 7772-99-8
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 685652_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
04/13/1988 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 8179 50 7 6 0 0 0 0 0 13 0.26 0.14 20.00 14.00
    8186 50 7 9 0 0 0 0 0 16 0.32 0.14 26.00 12.00
    8190 50 9 12 0 0 0 0 0 21 0.42 0.18 18.00 10.00
    8202 50 3 2 0 0 0 0 0 5 0.10 0.06 10.00 6.00
    8214 50 12 16 0 1 0 0 0 29 0.58 0.24 26.00 16.00
    8220 50 5 6 0 0 0 0 0 11 0.22 0.10 16.00 6.00
    8223 50 17 22 0 0 0 0 0 39 0.78 0.34 30.00 20.00
    8240 50 3 10 0 0 0 0 0 13 0.26 0.06 22.00 6.00
Average         7.9 10.4 0.0 0.1 0.0 0.0 0.0 18.4 0.37 0.16 21.00 11.25
± SEM                         0.08 0.03 2.27 1.85
 
Test Chemical Stannous chloride 
37.5       
 8216 50 2 4 0 0 0 0 0 6 0.12 0.04 10.00 4.00
    8219 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 2.00
    8224 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    8226 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    8230 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
    8233 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    8236 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    8249 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.8 1.6 0.0 0.0 0.0 0.0 0.0 2.4 0.05 0.02 3.75 1.25
± SEM                         0.01 0.01 1.03 0.53
 
Test Chemical Stannous chloride 
75         
 8217 50 1 0 0 2 0 0 0 3 0.06 0.02 6.00 2.00
    8221 50 0 3 0 0 0 0 0 3 0.06 0.00 2.00 0.00
    8225 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    8231 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    8238 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    8241 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    8250 50 0 5 0 0 0 0 0 5 0.10 0.00 6.00 0.00
    8251 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.1 1.4 0.0 0.3 0.0 0.0 0.0 1.8 0.04 0.00 2.50 0.25
± SEM                         0.01 0.00 0.82 0.25
 
Test Chemical Stannous chloride 
150         
 8213 50 2 3 0 0 0 0 0 5 0.10 0.04 8.00 4.00
    8218 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 4.00
    8222 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    8228 50 0 7 0 0 0 0 0 7 0.14 0.00 8.00 0.00
    8234 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    8235 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    8244 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    8245 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.0 1.6 0.0 0.0 0.0 0.0 0.0 2.6 0.05 0.02 4.00 2.00
± SEM                         0.02 0.01 1.25 0.85
 
Vehicle Control No Stressor 
 0         
 8175 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    8180 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    8185 50 2 2 0 0 0 0 1 5 0.10 0.06 8.00 4.00
    8197 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    8205 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    8227 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    8232 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    8247 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         1.3 1.3 0.0 0.0 0.0 0.0 0.1 2.6 0.05 0.03 5.00 2.50
± SEM                         0.01 0.01 1.00 0.82
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation