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Study Information
Study Attribute Value
CEBS Accession Number: 002-02837-0012-0000-5
Chemical Name: Stannous chloride
CASRN: 7772-99-8
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 685652_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
10/26/1988 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
25         
 10366 50 23 6 0 0 0 0 1 30 0.60 0.48 22.00 10.00
    10384 50 21 8 0 0 0 0 0 29 0.58 0.42 30.00 20.00
    10408 50 7 2 0 0 0 0 0 9 0.18 0.14 12.00 8.00
    10415 50 37 6 0 0 0 0 0 43 0.86 0.74 30.00 20.00
    10422 50 31 4 0 0 0 0 0 35 0.70 0.62 24.00 18.00
    10427 50 63 12 0 0 0 0 1 76 1.52 1.28 40.00 30.00
    10440 50 18 4 0 0 0 0 0 22 0.44 0.36 20.00 14.00
Average         28.6 6.0 0.0 0.0 0.0 0.0 0.3 34.9 0.70 0.58 25.43 17.14
± SEM                         0.16 0.14 3.37 2.79
 
Test Chemical Stannous chloride 
37.5       
 10423 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10424 50 13 4 0 0 0 0 0 17 0.34 0.26 16.00 8.00
    10431 50 2 10 0 0 0 0 0 12 0.24 0.04 18.00 4.00
    10432 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10435 50 0 1 0 0 0 0 1 2 0.04 0.02 2.00 0.00
    10441 50 14 2 0 0 0 0 0 16 0.32 0.28 8.00 8.00
    10445 50 4 5 0 0 0 0 0 9 0.18 0.08 16.00 8.00
Average         4.7 3.4 0.0 0.0 0.0 0.0 0.1 8.3 0.17 0.10 9.14 4.00
± SEM                         0.05 0.05 2.79 1.51
 
Test Chemical Stannous chloride 
75         
 10436 50 2 5 0 0 0 0 0 7 0.14 0.04 12.00 4.00
    10438 50 1 7 0 0 0 0 0 8 0.16 0.02 14.00 2.00
    10443 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10444 50 0 4 0 0 0 0 0 4 0.08 0.00 6.00 0.00
    10448 50 1 3 0 0 0 0 0 4 0.08 0.02 6.00 2.00
    10449 50 1 4 0 0 0 0 0 5 0.10 0.02 10.00 2.00
    10452 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
Average         0.9 3.7 0.0 0.0 0.0 0.0 0.0 4.6 0.09 0.02 8.00 1.71
± SEM                         0.02 0.01 1.57 0.52
 
Test Chemical Stannous chloride 
150         
 10425 50 3 5 0 0 0 0 0 8 0.16 0.06 12.00 4.00
    10428 50 3 6 0 0 0 0 0 9 0.18 0.06 14.00 4.00
    10446 50 3 2 0 0 0 0 0 5 0.10 0.06 8.00 6.00
    10447 50 4 5 0 0 0 0 0 9 0.18 0.08 16.00 8.00
    10450 50 1 3 0 0 0 0 0 4 0.08 0.02 6.00 2.00
    10451 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    10453 50 3 3 0 0 0 0 0 6 0.12 0.06 10.00 6.00
    10454 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
Average         2.5 3.4 0.0 0.0 0.0 0.0 0.0 5.9 0.12 0.05 9.50 4.50
± SEM                         0.02 0.01 1.50 0.73
 
Vehicle Control No Stressor 
 0         
 10367 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10372 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    10402 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10411 50 10 2 0 0 0 0 1 13 0.26 0.22 6.00 2.00
    10417 50 3 2 0 0 0 0 0 5 0.10 0.06 10.00 6.00
    10430 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    10433 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10437 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
Average         1.9 1.4 0.0 0.0 0.0 0.0 0.1 3.4 0.07 0.04 4.25 1.50
± SEM                         0.03 0.03 1.10 0.82
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation