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Study Information
Study Attribute Value
CEBS Accession Number: 002-02837-0012-0000-5
Chemical Name: Stannous chloride
CASRN: 7772-99-8
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 685652_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
08/22/1989 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
25         
 12912 50 24 2 1 0 0 0 0 27 0.54 0.50 14.00 10.00
    12916 50 10 12 1 0 0 1 0 24 0.48 0.24 22.00 20.00
    12922 50 14 3 0 0 0 0 0 17 0.34 0.28 18.00 12.00
    12933 50 6 8 0 0 0 0 1 15 0.30 0.14 18.00 12.00
    12934 50 1 4 0 0 0 0 0 5 0.10 0.02 8.00 4.00
    12936 50 2 3 0 0 0 0 1 6 0.12 0.06 10.00 4.00
    12943 50 25 4 0 0 2 0 0 31 0.62 0.54 22.00 16.00
    12945 50 18 4 0 0 1 0 2 25 0.50 0.42 24.00 18.00
Average         12.5 5.0 0.3 0.0 0.4 0.1 0.5 18.8 0.38 0.28 17.00 12.00
± SEM                         0.07 0.07 2.07 2.10
 
Test Chemical Stannous chloride 
112.5       
 12911 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 4.00
    12917 50 3 1 0 0 0 0 1 5 0.10 0.08 8.00 6.00
    12921 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12925 50 6 1 0 0 0 0 0 7 0.14 0.12 6.00 6.00
    12930 50 2 0 0 0 0 0 1 3 0.06 0.06 4.00 4.00
    12932 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12935 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12944 50 0 2 0 0 0 0 1 3 0.06 0.02 4.00 0.00
Average         1.6 0.9 0.0 0.0 0.0 0.0 0.4 2.9 0.06 0.04 3.75 2.50
± SEM                         0.02 0.02 0.88 0.98
 
Test Chemical Stannous chloride 
150         
 12915 50 3 0 0 0 0 0 2 5 0.10 0.10 6.00 6.00
    12918 50 4 2 0 1 0 0 2 9 0.18 0.12 18.00 12.00
    12919 50 4 2 1 0 0 0 1 8 0.16 0.12 8.00 4.00
    12924 50 2 3 0 0 0 0 0 5 0.10 0.04 10.00 4.00
    12931 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    12938 50 2 1 0 0 0 0 1 4 0.08 0.06 6.00 4.00
    12942 50 6 0 0 0 0 0 1 7 0.14 0.14 6.00 6.00
    12950 50 2 3 0 0 0 0 0 5 0.10 0.04 10.00 4.00
Average         3.1 1.6 0.1 0.1 0.0 0.0 0.9 5.9 0.12 0.08 9.00 5.50
± SEM                         0.01 0.01 1.41 0.98
 
Vehicle Control No Stressor 
 0         
 12913 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    12914 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12920 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12927 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12939 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12941 50 0 1 0 0 0 0 2 3 0.06 0.04 2.00 0.00
    12946 50 1 0 0 0 0 1 2 4 0.08 0.08 2.00 2.00
    12948 50 1 0 0 0 0 0 0 1 0.02 0.02 4.00 4.00
Average         0.8 0.5 0.0 0.0 0.0 0.1 0.5 1.9 0.04 0.03 2.50 1.75
± SEM                         0.01 0.01 0.50 0.45
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation