| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02837-0011-0000-4 |
| Chemical Name: | Stannous chloride |
| CASRN: | 7772-99-8 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 685652_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 12/09/1987 | Bone Marrow | 42 | Male | Mouse | B6C3F1 | IP/IJ x 1, 42 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
7069 | 25 | 7.19 | ± | 0.546 |
| 7073 | 25 | 7.19 | ± | 0.737 | |||
| 7082 | 25 | 6.77 | ± | 0.387 | |||
| 7111 | 25 | 7.43 | ± | 0.618 | |||
| Average | 7.14 | ± | 0.138 | ||||
| Test Chemical | Stannous chloride |
37.5 |
7058 | 25 | 6.23 | ± | 0.500 |
| 7063 | 25 | 7.26 | ± | 0.683 | |||
| 7065 | 25 | 8.08 | ± | 0.740 | |||
| 7074 | 25 | 6.63 | ± | 0.570 | |||
| Average | 7.06 | ± | 0.403 | ||||
| Test Chemical | Stannous chloride |
75 |
7055 | 25 | 6.74 | ± | 0.566 |
| 7057 | 25 | 7.01 | ± | 0.532 | |||
| 7064 | 25 | 7.65 | ± | 0.494 | |||
| 7068 | 25 | 7.85 | ± | 0.756 | |||
| Average | 7.33 | ± | 0.261 | ||||
| Test Chemical | Stannous chloride |
150 |
7059 | 25 | 9.19 | ± | 0.819 |
| 7060 | 25 | 5.82 | ± | 0.510 | |||
| 7061 | 25 | 10.19 | ± | 0.715 | |||
| 7066 | 25 | 10.49 | ± | 0.784 | |||
| Average | 8.92 | ± | 1.072 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
7056 | 25 | 14.76 | ± | 0.995 |
| 7067 | 25 | 12.38 | ± | 0.976 | |||
| 7092 | 25 | 14.40 | ± | 0.815 | |||
| 7102 | 25 | 14.30 | ± | 0.897 | |||
| Average | 13.97 | ± | 0.535 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed