| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02837-0011-0000-4 |
| Chemical Name: | Stannous chloride |
| CASRN: | 7772-99-8 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 685652_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 04/26/1988 | Bone Marrow | 42 | Male | Mouse | B6C3F1 | IP/IJ x 1, 42 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
8317 | 25 | 4.70 | ± | 0.420 |
| 8352 | 25 | 4.22 | ± | 0.383 | |||
| 8363 | 25 | 5.09 | ± | 0.298 | |||
| 8366 | 24 | 4.04 | ± | 0.425 | |||
| Average | 4.52 | ± | 0.236 | ||||
| Test Chemical | Stannous chloride |
112.5 |
8318 | 24 | 5.95 | ± | 0.626 |
| 8322 | 25 | 5.81 | ± | 0.596 | |||
| 8325 | 25 | 5.87 | ± | 0.494 | |||
| 8330 | 24 | 6.00 | ± | 0.576 | |||
| Average | 5.90 | ± | 0.042 | ||||
| Test Chemical | Stannous chloride |
150 |
8312 | 25 | 3.96 | ± | 0.279 |
| 8313 | 25 | 6.91 | ± | 0.698 | |||
| 8315 | 25 | 6.77 | ± | 0.513 | |||
| 8324 | 24 | 5.20 | ± | 0.456 | |||
| Average | 5.72 | ± | 0.700 | ||||
| Test Chemical | Stannous chloride |
187.5 |
8320 | 25 | 5.55 | ± | 0.703 |
| 8321 | 25 | 7.33 | ± | 0.594 | |||
| 8329 | 25 | 7.97 | ± | 0.757 | |||
| 8332 | 25 | 9.52 | ± | 0.699 | |||
| Average | 7.61 | ± | 0.820 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
8314 | 25 | 10.86 | ± | 0.779 |
| 8327 | 25 | 13.44 | ± | 1.092 | |||
| 8334 | 25 | 15.78 | ± | 1.183 | |||
| 8354 | 25 | 10.81 | ± | 0.837 | |||
| Average | 12.71 | ± | 1.189 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed