Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01865-0016-0000-9 |
Chemical Name: | Chlorodibromomethane |
CASRN: | 124-48-1 |
NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
NTP Study ID: | 687058_CA |
Study Result: | Positive |
Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.
Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Result |
---|---|---|---|---|---|---|---|
07/31/1986 | Bone Marrow | 17 | Male | Mouse | B6C3F1 | Intraperitoneal Injection x 1/study, 17 hour | Positive |
Dose (mg/kg) |
Animal Number |
No. Cells |
Chromatid | Isochromatid | Exchanges | Aberrations | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Breaks | Gaps | Breaks | Gaps | 'Tid | 'Some | Other | Total | Per Cell | % Cells w/ Abs | |||||||
(+ Gaps) | (- Gaps) | (+ Gaps) | (- Gaps) | |||||||||||||
Positive Control | Dimethylbenzanthracene |
100 |
3923 | 50 | 13 | 12 | 0 | 2 | 0 | 0 | 0 | 27 | 0.54 | 0.26 | 36.00 | 20.00 |
3924 | 50 | 6 | 2 | 0 | 0 | 0 | 0 | 0 | 8 | 0.16 | 0.12 | 16.00 | 12.00 | |||
3925 | 50 | 4 | 3 | 0 | 0 | 0 | 0 | 0 | 7 | 0.14 | 0.08 | 12.00 | 8.00 | |||
3926 | 50 | 10 | 3 | 2 | 0 | 1 | 0 | 1 | 17 | 0.34 | 0.28 | 24.00 | 22.00 | |||
3927 | 50 | 6 | 1 | 0 | 0 | 0 | 0 | 0 | 7 | 0.14 | 0.12 | 10.00 | 10.00 | |||
3928 | 50 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.04 | 6.00 | 4.00 | |||
3929 | 50 | 11 | 5 | 0 | 0 | 0 | 0 | 0 | 16 | 0.32 | 0.22 | 22.00 | 18.00 | |||
3930 | 50 | 3 | 2 | 0 | 0 | 0 | 0 | 0 | 5 | 0.10 | 0.06 | 8.00 | 6.00 | |||
Average | 6.9 | 3.6 | 0.3 | 0.3 | 0.1 | 0.0 | 0.1 | 11.3 | 0.23 | 0.15 | 16.75 | 12.50 | ||||
± SEM | 0.06 | 0.03 | 3.56 | 2.38 | ||||||||||||
Test Chemical | Chlorodibromomethane |
125 |
3873 | 50 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 7 | 0.14 | 0.14 | 14.00 | 14.00 |
3874 | 50 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 4 | 0.08 | 0.06 | 10.00 | 8.00 | |||
3875 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
3876 | 50 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.00 | 4.00 | 0.00 | |||
3877 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
3878 | 50 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.06 | 4.00 | 4.00 | |||
3879 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
3880 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
Average | 1.8 | 0.5 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.3 | 0.05 | 0.04 | 4.25 | 3.50 | ||||
± SEM | 0.02 | 0.02 | 1.83 | 1.80 | ||||||||||||
Test Chemical | Chlorodibromomethane |
250 |
3863 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 |
3864 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
3865 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
3866 | 50 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.04 | 4.00 | 4.00 | |||
3867 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
3868 | 50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.02 | 4.00 | 2.00 | |||
3869 | 50 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 3 | 0.06 | 0.02 | 6.00 | 2.00 | |||
3870 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
Average | 0.8 | 0.3 | 0.0 | 0.1 | 0.0 | 0.0 | 0.0 | 1.1 | 0.02 | 0.02 | 2.25 | 1.50 | ||||
± SEM | 0.01 | 0.01 | 0.80 | 0.50 | ||||||||||||
Test Chemical | Chlorodibromomethane |
500 |
3853 | 50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.02 | 4.00 | 2.00 |
3854 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
3855 | 50 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.04 | 4.00 | 4.00 | |||
3856 | 50 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.04 | 4.00 | 4.00 | |||
3857 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
3858 | 50 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.00 | 2.00 | 0.00 | |||
3859 | 50 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.00 | 2.00 | 0.00 | |||
3860 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
Average | 0.8 | 0.4 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.1 | 0.02 | 0.02 | 2.25 | 1.50 | ||||
± SEM | 0.01 | 0.01 | 0.59 | 0.63 | ||||||||||||
Vehicle Control | No Stressor |
0 |
3913 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 |
3914 | 50 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.00 | 6.00 | 0.00 | |||
3915 | 50 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.04 | 6.00 | 4.00 | |||
3916 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
3917 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
3918 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
3919 | 50 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.00 | 2.00 | 0.00 | |||
3920 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
Average | 0.4 | 0.6 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.0 | 0.02 | 0.01 | 2.00 | 0.75 | ||||
± SEM | 0.01 | 0.01 | 0.93 | 0.53 | ||||||||||||
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation