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Study Information
Study Attribute Value
CEBS Accession Number: 002-01865-0016-0000-9
Chemical Name: Chlorodibromomethane
CASRN: 124-48-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 687058_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
08/31/1988 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
50         
 8743 50 61 8 0 0 0 0 0 69 1.38 1.22 48.00 42.00
    8744 50 77 11 0 0 0 0 0 88 1.76 1.54 44.00 40.00
    8745 50 4 1 0 0 0 0 0 5 0.10 0.08 8.00 6.00
    8746 50 14 8 1 1 0 0 0 24 0.48 0.30 36.00 26.00
    8747 50 14 9 0 0 0 0 0 23 0.46 0.28 30.00 24.00
    8748 50 16 8 0 0 0 0 0 24 0.48 0.32 28.00 24.00
    8749 50 13 5 1 0 0 0 0 19 0.38 0.28 26.00 18.00
    8750 50 14 5 0 0 0 0 0 19 0.38 0.28 18.00 14.00
Average         26.6 6.9 0.3 0.1 0.0 0.0 0.0 33.9 0.68 0.54 29.75 24.25
± SEM                         0.20 0.19 4.64 4.32
 
Test Chemical Chlorodibromomethane 
125         
 8663 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    8664 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    8665 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    8666 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    8667 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    8668 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    8669 50 6 4 0 0 0 0 0 10 0.20 0.12 20.00 12.00
    8670 50 7 0 0 0 0 0 0 7 0.14 0.14 14.00 14.00
Average         3.1 0.9 0.0 0.0 0.0 0.0 0.0 4.0 0.08 0.06 8.00 6.25
± SEM                         0.02 0.02 2.27 1.67
 
Test Chemical Chlorodibromomethane 
250         
 8673 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    8674 50 4 1 0 0 0 0 0 5 0.10 0.08 10.00 8.00
    8675 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    8676 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    8677 50 5 0 0 0 0 0 0 5 0.10 0.10 8.00 8.00
    8678 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    8679 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    8680 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         2.4 0.6 0.0 0.0 0.0 0.0 0.0 3.0 0.06 0.05 5.75 4.50
± SEM                         0.01 0.01 1.03 0.91
 
Test Chemical Chlorodibromomethane 
500         
 8683 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    8684 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    8685 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    8686 50 16 3 0 0 0 0 0 19 0.38 0.32 32.00 30.00
    8687 50 15 3 0 0 0 0 0 18 0.36 0.30 36.00 30.00
    8688 50 5 2 0 1 0 0 0 8 0.16 0.10 14.00 10.00
    8689 50 14 6 0 0 0 0 0 20 0.40 0.28 26.00 20.00
    8690 50 14 8 0 0 0 0 0 22 0.44 0.28 34.00 26.00
Average         8.1 3.4 0.0 0.1 0.0 0.0 0.0 11.6 0.23 0.16 19.25 14.75
± SEM                         0.06 0.05 5.07 4.70
 
Vehicle Control No Stressor 
 0         
 8723 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    8724 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    8725 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    8726 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    8729 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    8730 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    8731 50 4 0 0 0 0 0 0 4 0.08 0.08 6.00 6.00
Average         1.3 0.9 0.0 0.0 0.0 0.0 0.0 2.1 0.04 0.03 4.00 2.29
± SEM                         0.01 0.01 0.87 0.81
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation