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Study Information
Study Attribute Value
CEBS Accession Number: 002-01865-0016-0000-9
Chemical Name: Chlorodibromomethane
CASRN: 124-48-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 687058_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
03/14/1989 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
50         
 9922 50 32 9 0 0 0 0 0 41 0.82 0.64 20.00 16.00
    9923 50 11 9 0 0 0 0 0 20 0.40 0.22 24.00 20.00
    9924 50 18 13 0 0 0 0 0 31 0.62 0.36 42.00 38.00
    9925 50 13 17 3 4 0 0 0 37 0.74 0.32 40.00 32.00
    9926 50 10 7 0 0 0 0 0 17 0.34 0.20 24.00 18.00
    9927 50 22 16 1 0 0 0 1 40 0.80 0.48 40.00 32.00
    9928 50 14 10 1 0 1 0 0 26 0.52 0.32 30.00 24.00
    9929 50 4 6 0 0 0 0 0 10 0.20 0.08 14.00 6.00
Average         15.5 10.9 0.6 0.5 0.1 0.0 0.1 27.8 0.56 0.33 29.25 23.25
± SEM                         0.08 0.06 3.70 3.68
 
Test Chemical Chlorodibromomethane 
250         
 9852 50 6 1 0 0 0 0 0 7 0.14 0.12 8.00 6.00
    9853 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9854 50 2 10 3 0 0 0 0 15 0.30 0.10 16.00 10.00
    9856 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    9857 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9858 50 3 5 0 0 0 0 0 8 0.16 0.06 8.00 4.00
    9859 50 8 6 0 0 0 0 0 14 0.28 0.16 22.00 12.00
    9860 50 1 2 0 1 0 0 0 4 0.08 0.02 8.00 2.00
Average         3.0 3.3 0.4 0.1 0.0 0.0 0.0 6.8 0.14 0.07 9.25 5.25
± SEM                         0.04 0.02 2.39 1.46
 
Test Chemical Chlorodibromomethane 
375         
 9862 50 1 2 2 0 0 0 0 5 0.10 0.06 6.00 4.00
    9863 50 3 2 3 0 0 0 0 8 0.16 0.12 14.00 10.00
    9864 50 3 4 0 0 0 0 0 7 0.14 0.06 8.00 6.00
    9865 50 1 3 1 0 0 0 0 5 0.10 0.04 10.00 4.00
    9866 50 2 3 2 0 0 0 0 7 0.14 0.08 10.00 6.00
    9867 50 2 0 2 0 0 0 0 4 0.08 0.08 8.00 8.00
    9868 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    9869 50 3 6 1 0 0 0 0 10 0.20 0.08 14.00 8.00
Average         2.0 2.8 1.4 0.0 0.0 0.0 0.0 6.1 0.12 0.07 9.25 6.00
± SEM                         0.02 0.01 1.25 0.93
 
Test Chemical Chlorodibromomethane 
500         
 9872 50 1 4 0 0 0 0 0 5 0.10 0.02 6.00 2.00
    9873 50 4 1 0 0 0 0 0 5 0.10 0.08 8.00 6.00
    9874 50 2 2 0 0 0 0 1 5 0.10 0.06 8.00 4.00
    9875 50 2 7 0 0 0 0 0 9 0.18 0.04 14.00 4.00
    9876 50 10 4 0 0 0 0 0 14 0.28 0.20 20.00 14.00
    9877 50 1 3 0 0 0 0 0 4 0.08 0.02 6.00 2.00
    9878 50 4 1 0 0 0 0 0 5 0.10 0.08 8.00 6.00
    9879 50 5 2 0 1 0 0 0 8 0.16 0.10 12.00 8.00
Average         3.6 3.0 0.0 0.1 0.0 0.0 0.1 6.9 0.14 0.08 10.25 5.75
± SEM                         0.02 0.02 1.71 1.39
 
Vehicle Control No Stressor 
 0         
 9912 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 2.00
    9913 50 7 2 0 0 0 0 0 9 0.18 0.14 12.00 10.00
    9914 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    9915 50 0 1 0 0 0 0 1 2 0.04 0.02 4.00 2.00
    9916 50 5 4 0 0 0 0 0 9 0.18 0.10 14.00 8.00
    9917 50 2 0 0 0 0 0 0 2 0.04 0.04 2.00 2.00
    9918 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    9919 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         2.5 1.4 0.0 0.0 0.0 0.0 0.1 4.0 0.08 0.05 6.25 4.00
± SEM                         0.02 0.02 1.53 1.13
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation