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Study Information
Study Attribute Value
CEBS Accession Number: 002-01865-0016-0000-9
Chemical Name: Chlorodibromomethane
CASRN: 124-48-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 687058_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
12/17/1990 Bone Marrow 35 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 35 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
50         
 11490 50 52 7 1 0 0 0 0 60 1.20 1.06 36.00 26.00
    11491 50 89 5 0 1 0 0 1 96 1.92 1.80 44.00 34.00
    11493 50 58 4 1 0 0 0 0 63 1.26 1.18 24.00 20.00
    11494 50 120 11 0 0 0 0 0 131 2.62 2.40 52.00 48.00
    11495 50 70 16 1 0 0 0 0 87 1.74 1.42 56.00 42.00
    11496 50 36 7 0 0 0 0 0 43 0.86 0.72 32.00 26.00
    11497 50 109 11 0 0 0 0 1 121 2.42 2.20 56.00 44.00
Average         76.3 8.7 0.4 0.1 0.0 0.0 0.3 85.9 1.72 1.54 42.86 34.29
± SEM                         0.25 0.23 4.76 4.03
 
Test Chemical Chlorodibromomethane 
250         
 11420 50 7 5 1 0 0 0 0 13 0.26 0.16 22.00 12.00
    11421 50 1 0 1 0 0 0 0 2 0.04 0.04 4.00 4.00
    11422 50 2 4 1 0 0 0 0 7 0.14 0.06 14.00 6.00
    11423 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11424 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11425 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    11426 50 1 5 0 0 0 0 0 6 0.12 0.02 10.00 2.00
    11427 50 4 3 0 0 0 0 0 7 0.14 0.08 14.00 8.00
Average         2.3 2.3 0.4 0.0 0.0 0.0 0.0 4.9 0.10 0.05 9.00 4.75
± SEM                         0.03 0.02 2.56 1.36
 
Test Chemical Chlorodibromomethane 
375         
 11430 50 4 5 0 0 0 0 0 9 0.18 0.08 10.00 6.00
    11431 50 1 4 0 0 0 0 0 5 0.10 0.02 12.00 4.00
    11432 50 3 2 0 0 0 0 0 5 0.10 0.06 8.00 6.00
    11433 50 6 0 0 0 0 0 0 6 0.12 0.12 10.00 10.00
    11434 50 3 2 0 0 0 0 0 5 0.10 0.06 8.00 4.00
    11435 50 4 2 0 0 0 0 0 6 0.12 0.08 12.00 8.00
    11436 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    11437 50 2 2 0 0 0 0 1 5 0.10 0.06 10.00 6.00
Average         3.3 2.3 0.0 0.0 0.0 0.0 0.1 5.6 0.11 0.07 9.75 6.25
± SEM                         0.01 0.01 0.59 0.70
 
Test Chemical Chlorodibromomethane 
500         
 11440 50 8 6 0 0 0 0 0 14 0.28 0.16 22.00 14.00
    11441 50 12 5 0 0 0 0 0 17 0.34 0.24 24.00 16.00
    11442 50 9 7 0 0 0 0 0 16 0.32 0.18 22.00 12.00
    11443 50 5 4 1 0 0 0 1 11 0.22 0.14 20.00 14.00
    11444 50 6 2 1 0 0 0 0 9 0.18 0.14 14.00 10.00
    11445 50 11 5 0 0 0 0 1 17 0.34 0.24 24.00 20.00
    11446 50 5 2 0 0 0 0 0 7 0.14 0.10 12.00 10.00
    11447 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         7.1 4.0 0.3 0.0 0.0 0.0 0.3 11.6 0.23 0.15 17.75 12.25
± SEM                         0.04 0.03 2.52 1.87
 
Vehicle Control No Stressor 
 0         
 11480 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11481 50 4 0 5 0 0 0 0 9 0.18 0.18 4.00 4.00
    11482 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11485 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    11486 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    11487 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11488 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11489 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         1.1 0.9 0.6 0.0 0.0 0.0 0.0 2.6 0.05 0.04 3.50 1.75
± SEM                         0.02 0.02 0.63 0.59
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation