| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01865-0015-0000-8 |
| Chemical Name: | Chlorodibromomethane |
| CASRN: | 124-48-1 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 687058_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 07/29/1986 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
3843 | 25 | 3.89 | ± | 0.353 |
| 3844 | 25 | 5.67 | ± | 0.643 | |||
| 3845 | 25 | 5.27 | ± | 0.548 | |||
| 3846 | 25 | 3.80 | ± | 0.454 | |||
| Average | 4.66 | ± | 0.478 | ||||
| Test Chemical | Chlorodibromomethane |
125 |
3823 | 25 | 4.39 | ± | 0.559 |
| 3825 | 25 | 3.84 | ± | 0.454 | |||
| 3826 | 25 | 3.35 | ± | 0.413 | |||
| 3827 | 25 | 3.66 | ± | 0.379 | |||
| Average | 3.81 | ± | 0.219 | ||||
| Test Chemical | Chlorodibromomethane |
250 |
3818 | 25 | 3.70 | ± | 0.374 |
| 3819 | 25 | 4.21 | ± | 0.406 | |||
| 3820 | 25 | 2.60 | ± | 0.250 | |||
| 3821 | 25 | 3.40 | ± | 0.321 | |||
| Average | 3.48 | ± | 0.336 | ||||
| Test Chemical | Chlorodibromomethane |
500 |
3813 | 25 | 3.09 | ± | 0.386 |
| 3814 | 25 | 4.59 | ± | 0.322 | |||
| 3815 | 25 | 3.92 | ± | 0.468 | |||
| 3817 | 25 | 4.29 | ± | 0.435 | |||
| Average | 3.97 | ± | 0.326 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
3848 | 25 | 9.87 | ± | 0.826 |
| 3849 | 25 | 8.83 | ± | 0.708 | |||
| 3850 | 25 | 8.67 | ± | 0.900 | |||
| 3851 | 25 | 7.57 | ± | 0.850 | |||
| Average | 8.74 | ± | 0.470 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed