| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01865-0015-0000-8 |
| Chemical Name: | Chlorodibromomethane |
| CASRN: | 124-48-1 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 687058_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 02/06/1989 | Bone Marrow | 42 | Male | Mouse | B6C3F1 | IP/IJ x 1, 42 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
9667 | 25 | 3.56 | ± | 0.496 |
| 9668 | 25 | 4.70 | ± | 0.379 | |||
| 9669 | 25 | 5.44 | ± | 0.643 | |||
| 9670 | 25 | 2.96 | ± | 0.414 | |||
| Average | 4.17 | ± | 0.557 | ||||
| Test Chemical | Chlorodibromomethane |
100 |
9632 | 25 | 4.68 | ± | 0.610 |
| 9633 | 25 | 3.65 | ± | 0.451 | |||
| 9634 | 25 | 4.03 | ± | 0.477 | |||
| 9635 | 25 | 4.35 | ± | 0.605 | |||
| Average | 4.17 | ± | 0.221 | ||||
| Test Chemical | Chlorodibromomethane |
200 |
9637 | 25 | 8.98 | ± | 0.605 |
| 9638 | 25 | 5.37 | ± | 0.505 | |||
| 9639 | 25 | 3.50 | ± | 0.458 | |||
| 9640 | 25 | 6.52 | ± | 0.593 | |||
| Average | 6.09 | ± | 1.146 | ||||
| Test Chemical | Chlorodibromomethane |
400 |
9642 | 25 | 3.89 | ± | 0.380 |
| 9643 | 25 | 3.17 | ± | 0.382 | |||
| 9644 | 25 | 5.45 | ± | 0.526 | |||
| 9645 | 25 | 5.10 | ± | 0.402 | |||
| Average | 4.40 | ± | 0.528 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
9672 | 25 | 8.78 | ± | 0.796 |
| 9673 | 25 | 10.26 | ± | 0.873 | |||
| 9674 | 25 | 5.53 | ± | 0.566 | |||
| 9675 | 25 | 9.78 | ± | 0.834 | |||
| Average | 8.59 | ± | 1.064 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed