| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-03100-0007-0000-3 |
| Chemical Name: | n-Hexane |
| CASRN: | 110-54-3 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 699016_SCE |
| Study Result: | Negative (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 06/11/1984 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
1591 | 25 | 4.73 | ± | 0.578 |
| 1592 | 25 | 5.65 | ± | 0.572 | |||
| 1593 | 25 | 5.26 | ± | 0.414 | |||
| 1594 | 25 | 5.40 | ± | 0.512 | |||
| Average | 5.26 | ± | 0.194 | ||||
| Test Chemical | n-Hexane |
500 |
1521 | 25 | 5.07 | ± | 0.671 |
| 1522 | 25 | 5.61 | ± | 0.628 | |||
| 1523 | 25 | 5.07 | ± | 0.439 | |||
| 1524 | 25 | 4.14 | ± | 0.446 | |||
| Average | 4.97 | ± | 0.305 | ||||
| Test Chemical | n-Hexane |
1000 |
1526 | 25 | 5.07 | ± | 0.659 |
| 1527 | 25 | 5.68 | ± | 0.509 | |||
| 1528 | 25 | 3.57 | ± | 0.370 | |||
| 1529 | 25 | 5.55 | ± | 0.587 | |||
| Average | 4.96 | ± | 0.484 | ||||
| Test Chemical | n-Hexane |
2000 |
1531 | 25 | 5.52 | ± | 0.674 |
| 1533 | 25 | 3.78 | ± | 0.414 | |||
| 1534 | 25 | 5.50 | ± | 0.634 | |||
| 1535 | 25 | 3.60 | ± | 0.395 | |||
| Average | 4.61 | ± | 0.527 | ||||
| Positive Control | Dimethylbenzanthracene |
10 |
1536 | 25 | 12.64 | ± | 1.406 |
| 1537 | 25 | 10.42 | ± | 0.803 | |||
| 1538 | 25 | 10.91 | ± | 1.173 | |||
| 1539 | 25 | 14.17 | ± | 1.233 | |||
| Average | 12.02 | ± | 0.855 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed