| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01515-0013-0000-8 |
| Chemical Name: | 4-Nitro-o-phenylenediamine |
| CASRN: | 99-56-9 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 704945_SCE |
| Study Result: | Negative (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 06/12/1984 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Dimethyl Sulfoxide |
0 |
1596 | 25 | 3.89 | ± | 0.473 |
| 1597 | 25 | 3.50 | ± | 0.511 | |||
| 1598 | 25 | 4.06 | ± | 0.396 | |||
| 1599 | 25 | 6.41 | ± | 1.051 | |||
| Average | 4.47 | ± | 0.658 | ||||
| Test Chemical | 4-Nitro-o-phenylenediamine |
250 |
1546 | 25 | 5.88 | ± | 0.773 |
| 1547 | 25 | 5.22 | ± | 0.578 | |||
| 1548 | 25 | 5.59 | ± | 0.799 | |||
| 1549 | 25 | 8.06 | ± | 1.225 | |||
| Average | 6.19 | ± | 0.638 | ||||
| Test Chemical | 4-Nitro-o-phenylenediamine |
500 |
1551 | 25 | 4.41 | ± | 0.547 |
| 1552 | 25 | 4.01 | ± | 0.608 | |||
| 1553 | 25 | 7.49 | ± | 0.715 | |||
| 1554 | 25 | 5.64 | ± | 0.640 | |||
| Average | 5.39 | ± | 0.781 | ||||
| Test Chemical | 4-Nitro-o-phenylenediamine |
1000 |
1556 | 25 | 6.89 | ± | 0.753 |
| 1557 | 25 | 7.84 | ± | 1.087 | |||
| 1558 | 12 | 5.25 | ± | 0.641 | |||
| 1689 | 25 | 6.17 | ± | 0.806 | |||
| Average | 6.72 | ± | 0.548 | ||||
| Positive Control | Dimethylbenzanthracene |
10 |
1541 | 25 | 14.47 | ± | 1.040 |
| 1542 | 25 | 10.12 | ± | 0.754 | |||
| 1543 | 25 | 13.22 | ± | 1.336 | |||
| 1544 | 25 | 13.34 | ± | 1.011 | |||
| Average | 12.79 | ± | 0.932 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed