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Study Information
Study Attribute Value
CEBS Accession Number: 002-02887-0015-0000-3
Chemical Name: Tetrahydrofuran
CASRN: 109-99-9
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 720076_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
02/19/1987 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 4762 50 5 2 1 0 0 0 0 8 0.16 0.12 16.00 12.00
    4782 50 4 2 0 0 0 1 1 8 0.16 0.12 12.00 10.00
    4795 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4799 50 0 0 0 0 0 0 2 2 0.04 0.04 4.00 4.00
    4813 50 4 3 0 0 0 0 0 7 0.14 0.08 12.00 8.00
    4818 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4820 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    4839 50 4 3 0 0 0 0 1 8 0.16 0.10 14.00 10.00
Average         2.4 1.5 0.1 0.0 0.0 0.1 0.5 4.6 0.09 0.06 8.25 6.00
± SEM                         0.02 0.02 2.05 1.60
 
Test Chemical Tetrahydrofuran 
500         
 4763 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4772 50 2 0 0 0 0 0 0 2 0.04 0.04 6.00 6.00
    4786 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    4796 50 2 0 0 0 0 1 0 3 0.06 0.06 4.00 4.00
    4800 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    4816 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    4824 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4834 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.3 0.3 0.0 0.0 0.0 0.1 0.0 1.6 0.03 0.03 3.25 2.75
± SEM                         0.01 0.01 0.75 0.84
 
Test Chemical Tetrahydrofuran 
1000         
 4775 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    4778 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4785 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4790 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    4802 50 1 3 0 0 0 0 0 4 0.08 0.02 6.00 2.00
    4806 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4837 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    4840 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.4 0.9 0.0 0.0 0.0 0.0 0.0 1.3 0.03 0.01 2.25 0.75
± SEM                         0.01 0.00 0.88 0.37
 
Test Chemical Tetrahydrofuran 
2000         
 4768 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    4777 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    4789 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    4798 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4825 50 5 1 0 0 0 0 0 6 0.12 0.10 12.00 10.00
    4829 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    4833 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    4842 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.9 1.4 0.0 0.0 0.0 0.0 0.0 2.3 0.05 0.02 4.50 1.75
± SEM                         0.01 0.01 1.40 1.22
 
Vehicle Control No Stressor 
 0         
 4773 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    4780 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 4.00
    4792 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4797 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4808 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    4817 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4827 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    4835 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         1.3 0.4 0.0 0.0 0.0 0.0 0.0 1.6 0.03 0.03 3.25 2.75
± SEM                         0.01 0.01 0.65 0.65
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation