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Study Information
Study Attribute Value
CEBS Accession Number: 002-02887-0015-0000-3
Chemical Name: Tetrahydrofuran
CASRN: 109-99-9
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 720076_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
03/09/1988 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 7855 50 6 3 0 0 0 0 4 13 0.26 0.20 16.00 12.00
    7874 50 6 2 1 0 0 0 1 10 0.20 0.16 16.00 12.00
    7879 50 3 1 0 0 0 0 3 7 0.14 0.12 10.00 8.00
    7899 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    7905 50 2 1 0 0 0 1 0 4 0.08 0.06 8.00 6.00
    7924 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    7935 50 2 2 1 0 0 0 6 11 0.22 0.18 16.00 14.00
    7938 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         3.1 1.3 0.3 0.0 0.0 0.1 1.8 6.5 0.13 0.11 10.00 8.00
± SEM                         0.03 0.02 1.89 1.51
 
Test Chemical Tetrahydrofuran 
500         
 7910 50 2 1 0 0 0 0 1 4 0.08 0.06 6.00 4.00
    7912 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    7913 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    7914 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7917 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    7921 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    7923 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7927 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
Average         0.4 0.5 0.0 0.0 0.0 0.0 0.4 1.3 0.03 0.02 1.75 0.75
± SEM                         0.01 0.01 0.80 0.53
 
Test Chemical Tetrahydrofuran 
1000         
 7901 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    7902 50 2 0 0 0 0 0 2 4 0.08 0.08 4.00 4.00
    7904 50 0 1 0 0 0 0 0 1 0.02 0.00 4.00 2.00
    7906 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    7911 50 0 0 0 0 0 0 1 1 0.02 0.02 2.00 2.00
    7920 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7922 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7925 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.6 0.1 0.0 0.0 0.0 0.0 0.4 1.1 0.02 0.02 2.00 1.75
± SEM                         0.01 0.01 0.65 0.59
 
Test Chemical Tetrahydrofuran 
2000         
 7900 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7907 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7909 50 1 1 0 0 0 0 1 3 0.06 0.04 4.00 2.00
    7916 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7918 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7919 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7926 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7928 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
Average         0.4 0.4 0.0 0.0 0.0 0.0 0.1 0.9 0.02 0.01 1.50 0.75
± SEM                         0.01 0.01 1.05 0.53
 
Vehicle Control No Stressor 
 0         
 7861 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7865 50 1 1 0 0 0 0 0 2 0.04 0.02 2.00 2.00
    7892 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7908 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    7915 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    7931 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7940 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7944 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.4 0.4 0.0 0.0 0.0 0.0 0.0 0.8 0.02 0.01 1.25 0.75
± SEM                         0.01 0.01 0.53 0.53
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation