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Study Information
Study Attribute Value
CEBS Accession Number: 002-02793-0022-0000-7
Chemical Name: Salicylazosulfapyridine
CASRN: 599-79-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 724355_CA
Study Result: Negative (Nonstandard Protocol)


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
11/07/1990 Bone Marrow 17 Male Mouse B6C3F1 Gavage x 1/study, 17 hour Negative (Nonstandard Protocol)

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 11330 50 0 2 0 0 0 0 0 2 0.04 0.00 6.00 2.00
    11331 50 11 3 1 0 0 0 0 15 0.30 0.24 18.00 12.00
    11333 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    11334 50 13 1 0 0 0 0 0 14 0.28 0.26 22.00 20.00
    11335 50 1 1 1 0 0 0 0 3 0.06 0.04 6.00 4.00
    11336 50 6 5 1 1 0 0 0 13 0.26 0.14 20.00 12.00
    11337 50 8 2 1 0 0 0 1 12 0.24 0.20 20.00 16.00
    11338 50 5 3 1 0 0 0 0 9 0.18 0.12 16.00 10.00
Average         5.8 2.1 0.6 0.1 0.0 0.0 0.1 8.8 0.18 0.13 14.00 10.00
± SEM                         0.04 0.03 2.62 2.24
 
Test Chemical Salicylazosulfapyridine 
1250         
 11260 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11261 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    11262 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11263 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    11264 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11265 50 4 1 0 0 0 0 0 5 0.10 0.08 8.00 8.00
    11266 50 1 0 1 0 0 0 0 2 0.04 0.04 4.00 4.00
    11267 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.0 0.9 0.1 0.0 0.0 0.0 0.0 2.0 0.04 0.02 3.50 2.25
± SEM                         0.01 0.01 0.91 0.96
 
Test Chemical Salicylazosulfapyridine 
2500         
 11270 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    11271 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11272 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    11273 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11274 50 1 1 2 0 0 0 0 4 0.08 0.06 8.00 6.00
    11275 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    11276 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    11277 50 3 0 1 0 0 0 0 4 0.08 0.08 8.00 8.00
Average         1.0 1.5 0.4 0.0 0.0 0.0 0.0 2.9 0.06 0.03 5.50 2.75
± SEM                         0.01 0.01 0.91 1.00
 
Test Chemical Salicylazosulfapyridine 
5000         
 11281 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    11282 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
    11283 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11284 50 4 3 0 0 0 0 0 7 0.14 0.08 12.00 6.00
    11285 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    11286 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    11287 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11288 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.0 1.5 0.0 0.0 0.0 0.0 0.0 2.5 0.05 0.02 4.50 1.75
± SEM                         0.02 0.01 1.40 0.96
 
Vehicle Control No Stressor 
 0         
 11320 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11321 50 2 4 0 0 0 0 0 6 0.12 0.04 10.00 4.00
    11322 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11324 50 2 3 0 0 0 0 0 5 0.10 0.04 6.00 4.00
    11325 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11326 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11327 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    11328 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         1.0 1.1 0.0 0.0 0.0 0.0 0.0 2.1 0.04 0.02 3.50 2.00
± SEM                         0.02 0.01 1.18 0.65
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation