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Study Information
Study Attribute Value
CEBS Accession Number: 002-01046-0016-0000-0
Chemical Name: 1,2-Dichlorobenzene (o-dichlorobenzene)
CASRN: 95-50-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 732739_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
08/21/1986 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 3873 50 8 9 0 0 0 0 0 17 0.34 0.16 16.00 12.00
    3883 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    3892 50 3 4 0 0 0 0 0 7 0.14 0.06 8.00 4.00
    3895 50 6 2 0 0 0 0 0 8 0.16 0.12 14.00 12.00
    3910 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    3921 50 5 4 0 0 0 0 0 9 0.18 0.10 12.00 6.00
    3933 50 3 3 0 0 0 0 1 7 0.14 0.08 12.00 8.00
    3937 50 5 4 1 0 0 0 2 12 0.24 0.16 18.00 14.00
Average         4.1 3.6 0.1 0.0 0.0 0.0 0.4 8.3 0.17 0.09 11.50 7.75
± SEM                         0.03 0.02 1.64 1.58
 
Test Chemical 1,2-Dichlorobenzene (o-dichlorobenzene) 
375         
 3865 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3869 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3879 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3889 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3893 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3894 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    3896 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    3900 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.8 0.3 0.0 0.0 0.0 0.0 0.0 1.0 0.02 0.02 2.00 1.50
± SEM                         0.01 0.01 0.53 0.50
 
Test Chemical 1,2-Dichlorobenzene (o-dichlorobenzene) 
750         
 3870 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    3874 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    3876 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    3878 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3884 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3886 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3887 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    3891 50 2 2 0 0 0 0 0 4 0.08 0.04 2.00 2.00
Average         1.1 0.8 0.0 0.0 0.0 0.0 0.0 1.9 0.04 0.02 3.00 2.00
± SEM                         0.01 0.01 1.07 0.93
 
Test Chemical 1,2-Dichlorobenzene (o-dichlorobenzene) 
1500         
 3875 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3877 50 1 0 1 0 0 0 0 2 0.04 0.04 4.00 4.00
    3880 50 2 3 0 0 0 0 0 5 0.10 0.04 8.00 4.00
    3881 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    3885 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3897 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3899 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 2.00
Average         1.1 0.7 0.1 0.0 0.0 0.0 0.0 2.0 0.04 0.03 3.43 2.29
± SEM                         0.01 0.01 1.13 0.68
 
Vehicle Control No Stressor 
 0         
 3866 50 2 2 0 0 0 0 0 4 0.08 0.04 2.00 2.00
    3868 50 2 0 0 0 0 0 1 3 0.06 0.06 4.00 4.00
    3890 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3901 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    3903 50 0 4 0 0 0 0 0 4 0.08 0.00 8.00 0.00
    3919 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    3929 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    3940 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
Average         0.9 1.8 0.0 0.0 0.0 0.0 0.1 2.8 0.06 0.02 4.25 1.50
± SEM                         0.01 0.01 0.70 0.50
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation