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Study Information
Study Attribute Value
CEBS Accession Number: 002-01046-0016-0000-0
Chemical Name: 1,2-Dichlorobenzene (o-dichlorobenzene)
CASRN: 95-50-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 732739_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
04/29/1987 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 5233 50 32 3 2 0 0 0 0 37 0.74 0.68 26.00 24.00
    5236 50 14 4 0 0 0 0 0 18 0.36 0.28 10.00 8.00
    5263 50 5 0 0 0 0 0 1 6 0.12 0.12 10.00 10.00
    5264 50 134 7 2 0 0 0 0 143 2.86 2.72 46.00 40.00
    5265 50 4 0 0 0 0 0 0 4 0.08 0.08 6.00 6.00
    5280 50 14 3 0 0 0 0 0 17 0.34 0.28 14.00 12.00
    5295 50 34 6 0 0 0 0 0 40 0.80 0.68 26.00 20.00
    5299 50 10 3 2 0 0 0 0 15 0.30 0.24 16.00 14.00
Average         30.9 3.3 0.8 0.0 0.0 0.0 0.1 35.0 0.70 0.64 19.25 16.75
± SEM                         0.32 0.31 4.61 3.94
 
Test Chemical 1,2-Dichlorobenzene (o-dichlorobenzene) 
150         
 5271 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    5272 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    5278 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    5279 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    5282 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    5287 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    5294 50 1 0 0 0 0 0 1 2 0.04 0.04 4.00 4.00
    5296 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         0.8 0.3 0.0 0.0 0.0 0.0 0.3 1.3 0.03 0.02 2.25 1.75
± SEM                         0.01 0.01 0.59 0.59
 
Test Chemical 1,2-Dichlorobenzene (o-dichlorobenzene) 
300         
 5266 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    5267 50 5 0 1 0 0 0 0 6 0.12 0.12 6.00 6.00
    5269 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    5270 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    5273 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    5281 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    5286 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    5289 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.0 0.4 0.1 0.0 0.0 0.0 0.0 1.5 0.03 0.02 2.25 1.50
± SEM                         0.01 0.01 0.88 0.82
 
Test Chemical 1,2-Dichlorobenzene (o-dichlorobenzene) 
600         
 5274 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    5290 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    5292 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    5293 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    5297 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    5298 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    5303 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    5304 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.6 0.1 0.0 0.0 0.0 0.0 0.0 0.8 0.02 0.01 1.50 1.25
± SEM                         0.01 0.01 1.05 0.84
 
Vehicle Control No Stressor 
 0         
 5245 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    5247 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    5255 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    5259 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    5260 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    5276 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    5285 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    5301 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.5 0.4 0.0 0.0 0.0 0.0 0.0 0.9 0.02 0.01 1.75 1.00
± SEM                         0.01 0.01 0.59 0.53
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation