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Study Information
Study Attribute Value
CEBS Accession Number: 002-01045-0018-0000-1
Chemical Name: 1,2-Dibromoethane
CASRN: 106-93-4
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 738945_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
04/17/1989 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 10002 50 15 5 0 0 0 0 0 20 0.40 0.30 22.00 18.00
    10003 50 8 5 0 0 0 0 0 13 0.26 0.16 22.00 16.00
    10004 50 8 6 2 0 0 0 0 16 0.32 0.20 22.00 16.00
    10005 50 9 0 0 0 0 0 1 10 0.20 0.20 18.00 18.00
    10006 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    10007 50 7 3 0 0 0 0 0 10 0.20 0.14 18.00 14.00
    10008 50 7 4 0 0 0 0 0 11 0.22 0.14 20.00 14.00
    10009 50 6 4 1 1 0 0 0 12 0.24 0.14 12.00 8.00
Average         7.9 3.5 0.4 0.1 0.0 0.0 0.1 12.0 0.24 0.17 17.75 13.75
± SEM                         0.03 0.02 1.83 1.58
 
Test Chemical 1,2-Dibromoethane 
37.5       
 9962 50 2 2 0 0 0 0 0 4 0.08 0.04 6.00 4.00
    9963 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9964 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9965 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9966 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9967 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9968 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    9969 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.0 0.3 0.0 0.0 0.0 0.0 0.0 1.3 0.03 0.02 2.25 2.00
± SEM                         0.01 0.01 0.88 0.76
 
Test Chemical 1,2-Dibromoethane 
75         
 9972 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9973 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9974 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9975 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9977 50 2 0 1 0 0 0 0 3 0.06 0.06 4.00 4.00
    9978 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9979 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9980 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         0.5 0.0 0.1 0.0 0.0 0.0 0.0 0.6 0.01 0.01 1.00 1.00
± SEM                         0.01 0.01 0.65 0.65
 
Test Chemical 1,2-Dibromoethane 
150         
 9982 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9983 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9984 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9985 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    9986 50 2 1 0 0 0 0 0 3 0.06 0.04 2.00 2.00
    9987 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9988 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    9989 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.1 0.4 0.0 0.0 0.0 0.0 0.0 1.5 0.03 0.02 2.50 2.00
± SEM                         0.01 0.00 0.63 0.38
 
Vehicle Control No Stressor 
 0         
 10001 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9992 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    9993 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    9994 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    9996 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9997 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9999 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.9 0.4 0.0 0.0 0.0 0.0 0.0 1.3 0.03 0.02 2.57 1.71
± SEM                         0.01 0.01 0.84 0.68
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation