COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01045-0018-0000-1
Chemical Name: 1,2-Dibromoethane
CASRN: 106-93-4
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 738945_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
01/05/1993 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
25         
 13354 50 79 5 0 0 0 0 0 84 1.68 1.58 34.00 26.00
    13355 50 64 3 1 0 0 0 0 68 1.36 1.30 22.00 18.00
    13356 50 77 11 1 0 0 0 0 89 1.78 1.56 42.00 30.00
    13357 50 108 5 0 0 0 0 0 113 2.26 2.16 34.00 26.00
    13358 50 120 6 1 0 0 0 0 127 2.54 2.42 46.00 38.00
    13359 50 37 9 1 0 0 0 0 47 0.94 0.76 40.00 30.00
    13360 50 60 9 1 0 0 0 0 70 1.40 1.22 32.00 28.00
    13361 50 51 4 0 0 0 0 0 55 1.10 1.02 30.00 24.00
Average         74.5 6.5 0.6 0.0 0.0 0.0 0.0 81.6 1.63 1.50 35.00 27.50
± SEM                         0.20 0.20 2.67 2.03
 
Test Chemical 1,2-Dibromoethane 
37.5       
 13314 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13315 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13316 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    13317 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    13318 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13319 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    13320 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13321 50 1 2 1 0 0 0 0 4 0.08 0.04 8.00 4.00
Average         0.4 0.9 0.1 0.0 0.0 0.0 0.0 1.4 0.03 0.01 2.50 1.00
± SEM                         0.01 0.01 0.98 0.53
 
Test Chemical 1,2-Dibromoethane 
75         
 13324 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13325 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13326 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    13327 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    13328 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13329 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    13330 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13331 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
Average         0.4 0.6 0.0 0.0 0.0 0.0 0.0 1.0 0.02 0.01 2.00 0.75
± SEM                         0.01 0.01 0.76 0.53
 
Test Chemical 1,2-Dibromoethane 
150         
 13334 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13335 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13337 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13338 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13339 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13340 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13341 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    13342 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.3 0.3 0.0 0.0 0.0 0.0 0.0 0.5 0.01 0.01 1.00 0.50
± SEM                         0.01 0.00 0.53 0.33
 
Vehicle Control No Stressor 
 0         
 13344 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    13345 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13346 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13347 50 0 0 1 0 0 0 0 1 0.02 0.02 2.00 2.00
    13348 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13349 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13350 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13351 50 2 0 0 0 0 0 0 2 0.04 0.04 2.00 2.00
Average         0.6 0.1 0.1 0.0 0.0 0.0 0.0 0.9 0.02 0.02 1.50 1.25
± SEM                         0.01 0.01 0.50 0.37
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation