COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01948-0014-0000-9
Chemical Name: D-Mannitol
CASRN: 69-65-8
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 741772_CA
Study Result: Negative (Nonstandard Protocol)


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
01/27/1987 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative (Nonstandard Protocol)

  Dose
(g/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 4540 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    4554 50 3 1 0 0 0 0 0 4 0.08 0.06 4.00 4.00
    4562 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4575 50 5 1 0 0 0 0 5 11 0.22 0.20 16.00 16.00
    4577 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    4584 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4594 50 6 1 0 0 0 0 0 7 0.14 0.12 14.00 12.00
    4604 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
Average         2.6 0.9 0.0 0.0 0.0 0.0 0.6 4.1 0.08 0.07 7.00 5.75
± SEM                         0.02 0.02 1.96 1.94
 
Test Chemical D-Mannitol 
2.5       
 4541 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    4550 50 0 0 0 0 0 1 0 1 0.02 0.02 2.00 2.00
    4579 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4583 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4592 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    4596 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    4599 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    4602 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.6 0.3 0.0 0.0 0.0 0.1 0.1 1.1 0.02 0.02 2.00 1.50
± SEM                         0.01 0.01 0.76 0.63
 
Test Chemical D-Mannitol 
5         
 4545 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    4546 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4551 50 1 0 1 0 0 0 0 2 0.04 0.04 4.00 4.00
    4552 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    4556 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 4.00
    4567 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4585 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4606 50 2 0 0 0 0 0 1 3 0.06 0.06 4.00 4.00
Average         0.6 0.5 0.1 0.0 0.0 0.0 0.1 1.4 0.03 0.02 2.50 1.75
± SEM                         0.01 0.01 0.73 0.70
 
Test Chemical D-Mannitol 
10         
 4544 50 4 0 0 0 0 0 0 4 0.08 0.08 8.00 8.00
    4549 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    4559 50 4 0 1 0 0 0 0 5 0.10 0.10 6.00 6.00
    4561 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4573 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4576 50 4 0 0 0 0 0 0 4 0.08 0.08 8.00 8.00
    4581 50 1 0 0 0 0 0 1 2 0.04 0.04 2.00 2.00
    4600 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         2.1 0.1 0.1 0.0 0.0 0.0 0.1 2.5 0.05 0.05 4.25 4.00
± SEM                         0.01 0.01 1.28 1.20
 
Vehicle Control No Stressor 
 0         
 4547 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    4565 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    4574 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    4580 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4582 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4587 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4591 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4601 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
Average         1.1 0.4 0.0 0.0 0.0 0.0 0.0 1.5 0.03 0.02 3.00 2.25
± SEM                         0.01 0.00 0.53 0.45
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation