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Study Information
Study Attribute Value
CEBS Accession Number: 002-01948-0014-0000-9
Chemical Name: D-Mannitol
CASRN: 69-65-8
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 741772_CA
Study Result: Negative (Nonstandard Protocol)


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
04/21/1987 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative (Nonstandard Protocol)

  Dose
(g/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 5129 50 9 3 0 0 0 0 0 12 0.24 0.18 18.00 14.00
    5134 50 3 1 0 0 0 0 1 5 0.10 0.08 10.00 8.00
    5139 50 6 2 0 0 0 0 1 9 0.18 0.14 14.00 12.00
    5151 50 5 1 0 0 0 0 1 7 0.14 0.12 12.00 12.00
    5162 50 6 1 0 0 0 0 2 9 0.18 0.16 18.00 16.00
    5166 50 3 2 0 0 0 0 0 5 0.10 0.06 6.00 4.00
    5175 50 0 0 0 0 0 0 1 1 0.02 0.02 2.00 2.00
    5178 50 0 0 0 0 0 0 2 2 0.04 0.04 4.00 4.00
Average         4.0 1.3 0.0 0.0 0.0 0.0 1.0 6.3 0.13 0.10 10.50 9.00
± SEM                         0.03 0.02 2.16 1.85
 
Test Chemical D-Mannitol 
5         
 5128 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    5130 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    5135 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    5136 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    5138 50 3 2 0 0 0 0 0 5 0.10 0.06 8.00 4.00
    5147 50 2 2 0 0 0 0 1 5 0.10 0.06 8.00 6.00
    5148 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    5153 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
Average         1.1 1.1 0.0 0.0 0.0 0.0 0.1 2.4 0.05 0.03 4.25 2.25
± SEM                         0.01 0.01 1.03 0.80
 
Test Chemical D-Mannitol 
10         
 5132 50 2 2 0 0 0 0 0 4 0.08 0.04 6.00 4.00
    5140 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    5144 50 3 3 0 0 0 0 0 6 0.12 0.06 6.00 4.00
    5152 50 0 0 0 0 0 0 1 1 0.02 0.02 2.00 2.00
    5155 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    5157 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    5158 50 0 0 0 0 0 0 1 1 0.02 0.02 2.00 2.00
    5159 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         1.5 0.8 0.0 0.0 0.0 0.0 0.3 2.5 0.05 0.04 4.00 3.25
± SEM                         0.01 0.01 0.65 0.37
 
Vehicle Control No Stressor 
 0         
 5145 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    5156 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    5160 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    5168 50 1 1 0 0 0 1 0 3 0.06 0.04 6.00 4.00
    5171 50 1 1 0 0 0 0 0 2 0.04 0.02 2.00 2.00
    5172 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    5173 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    5176 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.8 0.4 0.0 0.0 0.0 0.1 0.0 1.3 0.03 0.02 2.25 1.75
± SEM                         0.01 0.01 0.88 0.59
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation