| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02766-0017-0000-1 |
| Chemical Name: | Quinoline |
| CASRN: | 91-22-5 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 745521_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 09/30/1985 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
2730 | 25 | 5.14 | ± | 0.672 |
| 2731 | 25 | 6.71 | ± | 0.609 | |||
| 2732 | 25 | 5.14 | ± | 0.597 | |||
| 2733 | 25 | 5.05 | ± | 0.523 | |||
| Average | 5.51 | ± | 0.401 | ||||
| Test Chemical | Quinoline |
25 |
2700 | 25 | 2.53 | ± | 0.353 |
| 2701 | 25 | 4.53 | ± | 0.529 | |||
| 2702 | 25 | 3.53 | ± | 0.370 | |||
| 2703 | 25 | 6.57 | ± | 0.690 | |||
| Average | 4.30 | ± | 0.863 | ||||
| Test Chemical | Quinoline |
50 |
2705 | 25 | 2.90 | ± | 0.373 |
| 2706 | 25 | 2.89 | ± | 0.406 | |||
| 2707 | 25 | 5.00 | ± | 0.509 | |||
| 2708 | 25 | 3.26 | ± | 0.298 | |||
| Average | 3.51 | ± | 0.503 | ||||
| Test Chemical | Quinoline |
100 |
2710 | 25 | 4.45 | ± | 0.408 |
| 2711 | 25 | 3.56 | ± | 0.516 | |||
| 2712 | 25 | 4.37 | ± | 0.562 | |||
| 2713 | 25 | 3.76 | ± | 0.487 | |||
| Average | 4.03 | ± | 0.220 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
2735 | 25 | 10.84 | ± | 1.184 |
| 2736 | 25 | 8.33 | ± | 0.885 | |||
| 2737 | 25 | 9.39 | ± | 0.995 | |||
| 2738 | 25 | 8.82 | ± | 0.908 | |||
| Average | 9.34 | ± | 0.542 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed