| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02766-0017-0000-1 |
| Chemical Name: | Quinoline |
| CASRN: | 91-22-5 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 745521_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 05/12/1987 | Bone Marrow | 42 | Male | Mouse | B6C3F1 | IP/IJ x 1, 42 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
5495 | 25 | 6.68 | ± | 0.589 |
| 5496 | 25 | 2.53 | ± | 0.267 | |||
| 5497 | 25 | 3.62 | ± | 0.303 | |||
| 5498 | 25 | 6.00 | ± | 0.588 | |||
| Average | 4.70 | ± | 0.977 | ||||
| Test Chemical | Quinoline |
25 |
5465 | 25 | 2.97 | ± | 0.363 |
| 5466 | 25 | 4.27 | ± | 0.455 | |||
| 5467 | 25 | 4.09 | ± | 0.381 | |||
| 5468 | 25 | 3.53 | ± | 0.463 | |||
| Average | 3.71 | ± | 0.295 | ||||
| Test Chemical | Quinoline |
50 |
5470 | 25 | 4.20 | ± | 0.529 |
| 5471 | 25 | 3.52 | ± | 0.409 | |||
| 5472 | 25 | 5.53 | ± | 0.651 | |||
| 5473 | 25 | 3.85 | ± | 0.353 | |||
| Average | 4.27 | ± | 0.441 | ||||
| Test Chemical | Quinoline |
100 |
5475 | 25 | 3.64 | ± | 0.353 |
| 5476 | 25 | 4.54 | ± | 0.491 | |||
| 5477 | 25 | 4.30 | ± | 0.367 | |||
| 5478 | 25 | 4.36 | ± | 0.404 | |||
| Average | 4.21 | ± | 0.198 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
5500 | 25 | 9.41 | ± | 0.922 |
| 5501 | 25 | 9.98 | ± | 0.699 | |||
| 5502 | 25 | 6.57 | ± | 0.834 | |||
| 5503 | 25 | 11.09 | ± | 1.021 | |||
| Average | 9.27 | ± | 0.964 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed