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Study Information
Study Attribute Value
CEBS Accession Number: 002-02013-0015-0000-4
Chemical Name: Dichlorvos
CASRN: 62-73-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 755734_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
07/15/1983 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Test Chemical Dichlorvos 
6.25      
 661 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    666 50 3 6 2 0 0 0 123 134 2.68 2.56 10.00 4.00
    673 50 0 0 0 0 0 0 135 135 2.70 2.70 0.00 0.00
    674 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    684 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    903 50 0 1 0 0 0 0 2 3 0.06 0.04 2.00 0.00
    915 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    916 50 0 2 0 0 0 0 1 3 0.06 0.02 4.00 0.00
Average         0.5 1.8 0.3 0.0 0.0 0.0 32.8 35.3 0.71 0.67 3.50 0.75
± SEM                         0.43 0.43 1.30 0.53
 
Test Chemical Dichlorvos 
12.5       
 657 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    662 50 1 1 0 0 0 0 122 124 2.48 2.46 4.00 2.00
    663 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    664 50 0 2 0 0 0 0 2 4 0.08 0.04 2.00 0.00
    670 50 1 2 0 0 0 0 107 110 2.20 2.16 6.00 2.00
    671 50 1 1 0 0 0 0 0 2 0.04 0.02 2.00 2.00
    685 50 2 2 0 0 0 0 0 4 0.08 0.04 6.00 4.00
    686 50 1 1 0 0 0 0 1 3 0.06 0.04 4.00 2.00
Average         0.9 1.3 0.0 0.0 0.0 0.0 29.0 31.1 0.62 0.60 3.50 1.75
± SEM                         0.38 0.37 0.73 0.45
 
Test Chemical Dichlorvos 
25         
 653 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    656 50 1 2 0 0 0 0 136 139 2.78 2.74 4.00 2.00
    669 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    677 50 1 4 0 0 0 0 0 5 0.10 0.02 8.00 2.00
    679 50 3 2 0 0 0 0 1 6 0.12 0.08 10.00 6.00
    921 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    922 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    924 50 1 0 0 0 0 0 1 2 0.04 0.04 2.00 2.00
Average         0.9 1.0 0.0 0.0 0.0 0.0 17.3 19.1 0.38 0.36 3.25 1.75
± SEM                         0.34 0.34 1.36 0.70
 
Vehicle Control No Stressor 
 0         
 651 50 1 5 0 0 0 0 109 115 2.30 2.20 8.00 2.00
    654 50 1 1 0 0 0 0 83 85 1.70 1.68 4.00 2.00
    655 50 3 4 0 1 0 0 108 116 2.32 2.22 12.00 6.00
    658 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    665 50 2 0 0 0 0 0 1 3 0.06 0.06 2.00 2.00
    672 50 1 3 0 0 0 0 134 138 2.76 2.70 8.00 2.00
    675 50 2 3 0 0 0 0 1 6 0.12 0.06 8.00 4.00
    676 50 0 2 0 0 0 0 1 3 0.06 0.02 4.00 0.00
Average         1.4 2.6 0.0 0.1 0.0 0.0 54.6 58.8 1.18 1.12 6.75 2.50
± SEM                         0.43 0.42 1.13 0.63
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation