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Study Information
Study Attribute Value
CEBS Accession Number: 002-02013-0015-0000-4
Chemical Name: Dichlorvos
CASRN: 62-73-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 755734_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
03/09/1988 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 7855 50 6 3 0 0 0 0 4 13 0.26 0.20 16.00 12.00
    7874 50 6 2 1 0 0 0 1 10 0.20 0.16 16.00 12.00
    7879 50 3 1 0 0 0 0 3 7 0.14 0.12 10.00 8.00
    7899 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    7905 50 2 1 0 0 0 1 0 4 0.08 0.06 8.00 6.00
    7924 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    7935 50 2 2 1 0 0 0 6 11 0.22 0.18 16.00 14.00
    7938 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         3.1 1.3 0.3 0.0 0.0 0.1 1.8 6.5 0.13 0.11 10.00 8.00
± SEM                         0.03 0.02 1.89 1.51
 
Test Chemical Dichlorvos 
3.2       
 7856 50 0 1 0 0 0 0 1 2 0.04 0.02 2.00 0.00
    7860 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7877 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7881 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    7882 50 1 0 0 0 0 0 1 2 0.04 0.04 2.00 2.00
    7883 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7888 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7894 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.4 0.1 0.0 0.0 0.0 0.0 0.3 0.8 0.02 0.01 1.00 0.75
± SEM                         0.01 0.01 0.53 0.53
 
Test Chemical Dichlorvos 
6.5       
 7853 50 1 0 0 0 0 0 1 2 0.04 0.04 2.00 2.00
    7858 50 1 1 0 0 0 0 2 4 0.08 0.06 4.00 2.00
    7863 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    7869 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    7876 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    7884 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    7885 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    7890 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         1.0 0.9 0.0 0.0 0.0 0.0 0.4 2.3 0.05 0.03 3.75 2.00
± SEM                         0.01 0.01 0.80 0.76
 
Test Chemical Dichlorvos 
13         
 7857 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    7862 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    7864 50 1 1 0 0 0 0 2 4 0.08 0.06 4.00 2.00
    7868 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    7875 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7887 50 0 0 0 0 0 0 0 0 0.00 0.00 2.00 2.00
    7889 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    7896 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.6 0.6 0.0 0.0 0.0 0.0 0.3 1.5 0.03 0.02 2.75 1.50
± SEM                         0.01 0.01 0.75 0.50
 
Vehicle Control No Stressor 
 0         
 7861 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7865 50 1 1 0 0 0 0 0 2 0.04 0.02 2.00 2.00
    7892 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7908 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    7915 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    7931 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7940 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7944 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.4 0.4 0.0 0.0 0.0 0.0 0.0 0.8 0.02 0.01 1.25 0.75
± SEM                         0.01 0.01 0.53 0.53
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation