| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02013-0014-0000-3 |
| Chemical Name: | Dichlorvos |
| CASRN: | 62-73-7 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 755734_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 03/29/1988 | Bone Marrow | 42 | Male | Mouse | B6C3F1 | IP/IJ x 1, 42 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Phosphate Buffered Saline |
0 |
8093 | 25 | 5.84 | ± | 0.499 |
| 8102 | 25 | 4.61 | ± | 0.463 | |||
| 8106 | 24 | 4.99 | ± | 0.493 | |||
| 8118 | 25 | 6.76 | ± | 0.660 | |||
| Average | 5.54 | ± | 0.478 | ||||
| Test Chemical | Dichlorvos |
3.25 |
8113 | 25 | 3.94 | ± | 0.383 |
| 8116 | 25 | 4.37 | ± | 0.449 | |||
| 8119 | 25 | 9.81 | ± | 0.960 | |||
| 8125 | 25 | 4.06 | ± | 0.448 | |||
| Average | 5.54 | ± | 1.424 | ||||
| Test Chemical | Dichlorvos |
6.5 |
8111 | 25 | 4.46 | ± | 0.442 |
| 8114 | 25 | 4.25 | ± | 0.383 | |||
| 8124 | 25 | 6.09 | ± | 0.561 | |||
| 8126 | 25 | 5.88 | ± | 0.582 | |||
| Average | 5.17 | ± | 0.474 | ||||
| Test Chemical | Dichlorvos |
13 |
8107 | 25 | 4.63 | ± | 0.407 |
| 8108 | 25 | 4.87 | ± | 0.462 | |||
| 8120 | 25 | 4.04 | ± | 0.371 | |||
| 8122 | 25 | 5.27 | ± | 0.515 | |||
| Average | 4.70 | ± | 0.256 | ||||
| Positive Control | Mitomycin-C |
0.5 |
8104 | 25 | 9.56 | ± | 0.689 |
| 8109 | 25 | 9.40 | ± | 0.552 | |||
| 8115 | 25 | 9.88 | ± | 0.469 | |||
| 8123 | 25 | 12.49 | ± | 0.840 | |||
| Average | 10.32 | ± | 0.726 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed