| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01694-0015-0000-8 |
| Chemical Name: | Benzidine dihydrochloride |
| CASRN: | 531-85-1 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 758694_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 03/20/1985 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
2082 | 25 | 2.36 | ± | 0.251 |
| 2083 | 25 | 2.92 | ± | 0.346 | |||
| 2084 | 25 | 4.12 | ± | 0.376 | |||
| 2085 | 25 | 4.05 | ± | 0.366 | |||
| Average | 3.37 | ± | 0.432 | ||||
| Test Chemical | Benzidine dihydrochloride |
50 |
2068 | 25 | 5.60 | ± | 0.510 |
| 2069 | 25 | 7.74 | ± | 0.665 | |||
| 2070 | 25 | 5.18 | ± | 0.523 | |||
| 2071 | 25 | 5.96 | ± | 0.691 | |||
| Average | 6.12 | ± | 0.563 | ||||
| Test Chemical | Benzidine dihydrochloride |
100 |
2072 | 25 | 7.03 | ± | 0.757 |
| 2073 | 25 | 5.96 | ± | 0.596 | |||
| 2074 | 25 | 7.02 | ± | 0.751 | |||
| 2075 | 25 | 4.84 | ± | 0.528 | |||
| Average | 6.21 | ± | 0.522 | ||||
| Test Chemical | Benzidine dihydrochloride |
200 |
2077 | 25 | 8.29 | ± | 0.731 |
| 2078 | 25 | 5.75 | ± | 0.526 | |||
| 2079 | 25 | 5.80 | ± | 0.523 | |||
| 2080 | 25 | 7.09 | ± | 0.565 | |||
| Average | 6.73 | ± | 0.605 | ||||
| Positive Control | Dimethylbenzanthracene |
100 |
2087 | 25 | 14.11 | ± | 1.123 |
| 2088 | 25 | 10.78 | ± | 0.814 | |||
| 2089 | 25 | 15.24 | ± | 1.363 | |||
| 2090 | 25 | 13.02 | ± | 1.329 | |||
| Average | 13.27 | ± | 0.951 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed