| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01694-0015-0000-8 |
| Chemical Name: | Benzidine dihydrochloride |
| CASRN: | 531-85-1 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 758694_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 02/10/1987 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
5035 | 25 | 5.33 | ± | 0.411 |
| 5036 | 25 | 3.45 | ± | 0.420 | |||
| 5037 | 25 | 3.05 | ± | 0.324 | |||
| 5038 | 25 | 5.65 | ± | 0.518 | |||
| Average | 4.37 | ± | 0.655 | ||||
| Test Chemical | Benzidine dihydrochloride |
50 |
5005 | 25 | 5.50 | ± | 0.566 |
| 5006 | 25 | 8.04 | ± | 0.610 | |||
| 5007 | 25 | 9.96 | ± | 0.817 | |||
| 5008 | 25 | 6.26 | ± | 0.617 | |||
| Average | 7.44 | ± | 0.995 | ||||
| Test Chemical | Benzidine dihydrochloride |
100 |
5010 | 25 | 6.25 | ± | 0.515 |
| 5011 | 25 | 6.71 | ± | 0.552 | |||
| 5012 | 25 | 7.46 | ± | 0.547 | |||
| 5013 | 25 | 7.18 | ± | 0.608 | |||
| Average | 6.90 | ± | 0.266 | ||||
| Test Chemical | Benzidine dihydrochloride |
200 |
5015 | 25 | 8.39 | ± | 0.737 |
| 5016 | 25 | 9.92 | ± | 0.552 | |||
| 5017 | 25 | 13.27 | ± | 0.989 | |||
| 5019 | 25 | 7.73 | ± | 0.669 | |||
| Average | 9.83 | ± | 1.236 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
5040 | 25 | 8.18 | ± | 0.679 |
| 5042 | 25 | 9.19 | ± | 0.909 | |||
| 5043 | 25 | 11.29 | ± | 1.029 | |||
| 5044 | 25 | 10.71 | ± | 0.974 | |||
| Average | 9.84 | ± | 0.710 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed