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Study Information
Study Attribute Value
CEBS Accession Number: 002-01889-0013-0000-2
Chemical Name: Cinnamyl anthranilate
CASRN: 87-29-6
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 764473_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
09/17/1990 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
50         
 11251 50 89 11 0 0 0 0 0 100 2.00 1.78 46.00 34.00
    11252 50 49 10 1 2 0 0 0 62 1.24 1.00 50.00 34.00
    11253 50 29 18 1 0 0 0 1 49 0.98 0.62 44.00 28.00
    11254 50 38 5 0 0 0 0 1 44 0.88 0.78 34.00 28.00
    11255 50 59 15 0 0 0 0 0 74 1.48 1.18 44.00 26.00
    11256 50 76 8 1 0 0 0 0 85 1.70 1.54 30.00 20.00
    11257 50 124 4 3 0 0 0 0 131 2.62 2.54 52.00 46.00
    11259 50 32 12 0 0 0 0 0 44 0.88 0.64 20.00 10.00
Average         62.0 10.4 0.8 0.3 0.0 0.0 0.3 73.6 1.47 1.26 40.00 28.25
± SEM                         0.22 0.23 3.89 3.75
 
Test Chemical Cinnamyl anthranilate 
1250         
 11210 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11211 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11212 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11213 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11215 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11216 50 0 0 0 0 0 0 1 1 0.02 0.02 2.00 2.00
    11217 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11218 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.3 0.4 0.0 0.0 0.0 0.0 0.1 0.8 0.02 0.01 1.50 0.75
± SEM                         0.01 0.00 0.50 0.37
 
Test Chemical Cinnamyl anthranilate 
2500         
 11220 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11221 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11222 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11223 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11224 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11225 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11226 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11227 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.5 0.01 0.01 1.00 0.75
± SEM                         0.01 0.01 0.53 0.53
 
Test Chemical Cinnamyl anthranilate 
5000         
 11230 50 2 0 0 0 0 0 0 2 0.04 0.04 2.00 2.00
    11231 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    11232 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11233 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11234 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11235 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11236 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11237 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.6 0.1 0.0 0.0 0.0 0.0 0.0 0.8 0.02 0.01 1.25 1.00
± SEM                         0.01 0.01 0.53 0.53
 
Vehicle Control No Stressor 
 0         
 11240 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11241 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11242 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11243 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    11244 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11245 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11246 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11247 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
Average         0.5 0.5 0.0 0.0 0.0 0.0 0.0 1.0 0.02 0.01 2.00 1.00
± SEM                         0.01 0.01 0.93 0.53
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation