| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01889-0012-0000-1 |
| Chemical Name: | Cinnamyl anthranilate |
| CASRN: | 87-29-6 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 764473_SCE |
| Study Result: | Negative (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 10/15/1986 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Dimethyl Sulfoxide |
0 |
4446 | 25 | 4.42 | ± | 0.559 |
| 4447 | 25 | 4.92 | ± | 0.472 | |||
| 4448 | 25 | 3.73 | ± | 0.417 | |||
| 4449 | 25 | 4.41 | ± | 0.629 | |||
| Average | 4.38 | ± | 0.244 | ||||
| Test Chemical | Cinnamyl anthranilate |
1250 |
4426 | 25 | 4.57 | ± | 0.439 |
| 4427 | 25 | 4.90 | ± | 0.495 | |||
| 4428 | 25 | 5.39 | ± | 0.550 | |||
| 4429 | 25 | 3.09 | ± | 0.454 | |||
| Average | 4.48 | ± | 0.496 | ||||
| Test Chemical | Cinnamyl anthranilate |
2500 |
4421 | 25 | 4.08 | ± | 0.472 |
| 4422 | 25 | 2.45 | ± | 0.343 | |||
| 4423 | 25 | 2.88 | ± | 0.279 | |||
| 4424 | 25 | 4.66 | ± | 0.513 | |||
| Average | 3.52 | ± | 0.514 | ||||
| Test Chemical | Cinnamyl anthranilate |
5000 |
4416 | 25 | 3.69 | ± | 0.524 |
| 4417 | 25 | 2.88 | ± | 0.366 | |||
| 4418 | 25 | 4.02 | ± | 0.426 | |||
| 4419 | 25 | 3.83 | ± | 0.467 | |||
| Average | 3.60 | ± | 0.250 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
4451 | 25 | 10.78 | ± | 1.009 |
| 4452 | 25 | 11.94 | ± | 0.696 | |||
| 4453 | 25 | 9.08 | ± | 1.000 | |||
| 4454 | 25 | 10.08 | ± | 0.950 | |||
| Average | 10.46 | ± | 0.602 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed