Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01468-0014-0000-6 |
Chemical Name: | 4,4'-Oxydianiline |
CASRN: | 101-80-4 |
NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
NTP Study ID: | 774801_CA |
Study Result: | Positive |
Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.
Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Result |
---|---|---|---|---|---|---|---|
05/20/1986 | Bone Marrow | 17 | Male | Mouse | B6C3F1 | Intraperitoneal Injection x 1/study, 17 hour | Positive |
Dose (mg/kg) |
Animal Number |
No. Cells |
Chromatid | Isochromatid | Exchanges | Aberrations | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Breaks | Gaps | Breaks | Gaps | 'Tid | 'Some | Other | Total | Per Cell | % Cells w/ Abs | |||||||
(+ Gaps) | (- Gaps) | (+ Gaps) | (- Gaps) | |||||||||||||
Positive Control | Dimethylbenzanthracene |
100 |
3473 | 50 | 28 | 8 | 1 | 0 | 0 | 0 | 1 | 38 | 0.76 | 0.60 | 38.00 | 34.00 |
3474 | 50 | 5 | 6 | 0 | 2 | 0 | 0 | 0 | 13 | 0.26 | 0.10 | 16.00 | 6.00 | |||
3475 | 50 | 3 | 0 | 0 | 0 | 2 | 0 | 0 | 5 | 0.10 | 0.10 | 10.00 | 10.00 | |||
3476 | 50 | 8 | 6 | 1 | 1 | 2 | 0 | 0 | 18 | 0.36 | 0.22 | 24.00 | 16.00 | |||
3477 | 50 | 13 | 7 | 1 | 0 | 0 | 0 | 0 | 21 | 0.42 | 0.28 | 28.00 | 20.00 | |||
3478 | 50 | 10 | 4 | 0 | 0 | 0 | 0 | 0 | 14 | 0.28 | 0.20 | 22.00 | 16.00 | |||
3479 | 50 | 8 | 1 | 0 | 0 | 0 | 0 | 0 | 9 | 0.18 | 0.16 | 12.00 | 12.00 | |||
3480 | 50 | 10 | 6 | 0 | 0 | 0 | 0 | 0 | 16 | 0.32 | 0.20 | 24.00 | 16.00 | |||
Average | 10.6 | 4.8 | 0.4 | 0.4 | 0.5 | 0.0 | 0.1 | 16.8 | 0.34 | 0.23 | 21.75 | 16.25 | ||||
± SEM | 0.07 | 0.06 | 3.22 | 2.96 | ||||||||||||
Test Chemical | 4,4'-Oxydianiline |
125 |
3463 | 50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.02 | 2.00 | 2.00 |
3464 | 50 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.04 | 6.00 | 4.00 | |||
3465 | 50 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.00 | 2.00 | 0.00 | |||
3466 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
3467 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
3468 | 50 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.04 | 4.00 | 4.00 | |||
3469 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
3470 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
Average | 0.9 | 0.4 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.3 | 0.03 | 0.02 | 2.25 | 1.75 | ||||
± SEM | 0.01 | 0.01 | 0.70 | 0.59 | ||||||||||||
Test Chemical | 4,4'-Oxydianiline |
250 |
3453 | 50 | 4 | 0 | 0 | 0 | 1 | 0 | 0 | 5 | 0.10 | 0.10 | 10.00 | 10.00 |
3454 | 50 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.04 | 4.00 | 4.00 | |||
3455 | 50 | 4 | 1 | 0 | 0 | 0 | 0 | 0 | 5 | 0.10 | 0.08 | 8.00 | 8.00 | |||
3456 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
3457 | 50 | 3 | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 0.08 | 0.08 | 6.00 | 6.00 | |||
3458 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
3459 | 50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.02 | 4.00 | 2.00 | |||
3460 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
Average | 1.8 | 0.3 | 0.0 | 0.0 | 0.1 | 0.0 | 0.1 | 2.3 | 0.05 | 0.04 | 4.00 | 3.75 | ||||
± SEM | 0.02 | 0.01 | 1.36 | 1.39 | ||||||||||||
Test Chemical | 4,4'-Oxydianiline |
500 |
3443 | 50 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 4 | 0.08 | 0.06 | 8.00 | 6.00 |
3444 | 50 | 3 | 0 | 0 | 1 | 0 | 0 | 0 | 4 | 0.08 | 0.06 | 8.00 | 6.00 | |||
3445 | 50 | 6 | 2 | 0 | 2 | 0 | 0 | 0 | 10 | 0.20 | 0.12 | 16.00 | 12.00 | |||
3446 | 50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.02 | 4.00 | 2.00 | |||
3447 | 50 | 2 | 1 | 0 | 1 | 0 | 0 | 0 | 4 | 0.08 | 0.04 | 8.00 | 4.00 | |||
3448 | 50 | 2 | 1 | 0 | 1 | 0 | 0 | 0 | 4 | 0.08 | 0.04 | 8.00 | 4.00 | |||
3449 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
3450 | 50 | 2 | 2 | 0 | 2 | 0 | 0 | 0 | 6 | 0.12 | 0.04 | 8.00 | 4.00 | |||
Average | 2.4 | 1.0 | 0.0 | 0.9 | 0.0 | 0.0 | 0.0 | 4.3 | 0.09 | 0.05 | 7.50 | 4.75 | ||||
± SEM | 0.02 | 0.01 | 1.59 | 1.25 | ||||||||||||
Vehicle Control | No Stressor |
0 |
3483 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 |
3484 | 50 | 1 | 5 | 0 | 0 | 0 | 0 | 0 | 6 | 0.12 | 0.02 | 10.00 | 2.00 | |||
3485 | 50 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.04 | 6.00 | 4.00 | |||
3486 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
3487 | 50 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.04 | 4.00 | 4.00 | |||
3488 | 50 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.04 | 2.00 | 2.00 | |||
3489 | 50 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.04 | 6.00 | 4.00 | |||
3490 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
Average | 1.4 | 0.9 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.3 | 0.05 | 0.03 | 4.00 | 2.50 | ||||
± SEM | 0.01 | 0.01 | 1.13 | 0.50 | ||||||||||||
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation